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Table 1 LS associated with autoimmune diseases, presence of autoantibodies, treatment and response

From: A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report

Case

Age, sex

Morphea’s location

Associated autoimmune condition

Positive autoantibodies

Treatment

Response to treatment

Ref.

1

48-year-old woman

Plaques over the trunk

Vitiligo, Hashimoto’s thyroiditis

Antithyroglobu- lin antibody, anti-thyroid peroxidaz

Not described

Not described

3

2

16-year-old girl

On her trunk and right arm.

Necrotizing vas- culitis of arterioles within the subcutaneous fat and muscles. Mononeuritis multiplex.

Lupus anticoaglant test, Anti-DNA antibody, (LE) test, Anticardiolipin-β2GPI antibody

Pulse therapy with 1 g methyl prednisolone for 3 days, cyclophosphamide (50 mg/d).

Gradually improved

13

3

16-year-old girl

Umbilical region, right hemi thorax and back of the right hand

Idiopathic thrombocytopenic purpura

ANAS, Anti DNA

Not described

Not described

6

4

22-year-old woman

Anterior chest

Idiopathic thrombocytopenic purpura

None

Not described

Not described

6

Our case

53 year old woman

Atrophic violaceous plaques in the lower limbs

Vitiligo, autoimmune hypothyroidism, neumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis

Anti-microsomal and Anti-thyroglobulin antibodies

Methylprednisolone 1 gr/day per five days) and intravenous cyclophosphamide (1 gr monthly

Clinical improvement