Case | Age, sex | Morphea’s location | Associated autoimmune condition | Positive autoantibodies | Treatment | Response to treatment | Ref. |
---|---|---|---|---|---|---|---|
1 | 48-year-old woman | Plaques over the trunk | Vitiligo, Hashimoto’s thyroiditis | Antithyroglobu- lin antibody, anti-thyroid peroxidaz | Not described | Not described | 3 |
2 | 16-year-old girl | On her trunk and right arm. | Necrotizing vas- culitis of arterioles within the subcutaneous fat and muscles. Mononeuritis multiplex. | Lupus anticoaglant test, Anti-DNA antibody, (LE) test, Anticardiolipin-β2GPI antibody | Pulse therapy with 1 g methyl prednisolone for 3 days, cyclophosphamide (50 mg/d). | Gradually improved | 13 |
3 | 16-year-old girl | Umbilical region, right hemi thorax and back of the right hand | Idiopathic thrombocytopenic purpura | ANAS, Anti DNA | Not described | Not described | 6 |
4 | 22-year-old woman | Anterior chest | Idiopathic thrombocytopenic purpura | None | Not described | Not described | 6 |
Our case | 53 year old woman | Atrophic violaceous plaques in the lower limbs | Vitiligo, autoimmune hypothyroidism, neumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis | Anti-microsomal and Anti-thyroglobulin antibodies | Methylprednisolone 1 gr/day per five days) and intravenous cyclophosphamide (1 gr monthly | Clinical improvement |