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Table 2 Univariate and multivariate analysis of overall survival (OS) of patients with unfavorable cancer of unknown primary site (n = 179)

From: Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study

Variable N Median OS, months Univariate P Multivariate
     HR 95% CI P
Age, years       
   < 65 60 5.33 .309    
   ≥ 65 119 6.47     
Gender       
   Male 128 5.63 .467    
   Female 51 6.47     
Performance status     2.025 1.294-3.168 .002
   0-1 86 13.37 < .001    
   2-4 93 3.47     
Body mass index       
   < 24 83 5.33 .223    
   ≥ 24 53 11.8     
Histology       
   Adenocarcinoma 71 4.47 .402    
   Carcinoma, unspecified 83 6.47     
   Squamous cell carcinoma 6 59.7     
   Others 19 11.1     
Histologic grade       
   Poorly differentiated or Undifferentiated 31 7.03 .869    
   Unspecified 148 5.63     
Liver metastases       
   Yes 80 5.1 .236    
   No 99 7.7     
Lung metastases       
   Yes 87 4.43 .005    
   No 92 9.2     
Bone metastases       
   Yes 74 5.33 .255    
   No 105 6.43     
Lymph node metastases       
   Yes 107 6.17 .658    
   No 72 6.47     
No. of metastatic organs     1.927 1.147-3.237 .013
   1 40 18.07 .028    
   ≥ 2 139 5.33     
Radiotherapy       
   Yes 52 11.1 .105    
   No 127 5.07     
Chemotherapy     3.211 2.009-5.132 < .001
   Yes 118 9.2 < .001    
   No 61 1.63     
Albumin     2.216 1.440-3.409 < .001
   < 3.5 g/dl 66 2.77 < .001    
   ≥ 3.5 g/dl 113 11.1     
Estimated creatinine clearance       
   < 60 ml/min 75 6.43 .806    
   ≥ 60 ml/min 74 6.17     
Corrected Ca level     4.421 1.529-12.784 .006
   < 10.7 mg/dl 171 6.47 .006    
   ≥ 10.7 mg/dl 6 0.57     
Lactate dehydrogenase       
   < 250 U/L 76 10.67 .001    
   ≥ 250 U/L 102 3.67     
Na       
   < 135 mmol/l 55 2.07 < .001    
   ≥ 135 mmol/l 124 9.0     
Cholesterol       
   < 150 mg/dl 56 4.07 .014    
   ≥ 150 mg/dl 110 9.2     
Alkaline phosphatase       
   < 100 U/L 80 7.03 .569    
   ≥ 100 U/L 99 5.63     
WBC count (× 103 cells/μL)       
   < 10.0 124 10.27 < .001    
   > 10.0 55 3.23     
Lymphocyte count       
   < 700/μL 17 2.67 .003    
   ≥ 700/μL 162 7.03     
Hemoglobin level       
   < 11 g/dl 67 5.33 .091    
   ≥ 11 g/dl 112 7.73     
Platelet count       
   < 150 × 109/L 33 4.87 .82    
   ≥ 150 × 109/L 146 6.43     
  1. HR, hazard ratio; CI, confidence interval; WBC, white blood cell.