Variable
|
N
|
Median OS, months
|
Univariate P
|
Multivariate
|
---|
| | | |
HR
|
95% CI
|
P
|
---|
Age, years
| | | | | | |
< 65
|
60
|
5.33
|
.309
| | | |
≥ 65
|
119
|
6.47
| | | | |
Gender
| | | | | | |
Male
|
128
|
5.63
|
.467
| | | |
Female
|
51
|
6.47
| | | | |
Performance status
| | | |
2.025
|
1.294-3.168
|
.002
|
0-1
|
86
|
13.37
|
< .001
| | | |
2-4
|
93
|
3.47
| | | | |
Body mass index
| | | | | | |
< 24
|
83
|
5.33
|
.223
| | | |
≥ 24
|
53
|
11.8
| | | | |
Histology
| | | | | | |
Adenocarcinoma
|
71
|
4.47
|
.402
| | | |
Carcinoma, unspecified
|
83
|
6.47
| | | | |
Squamous cell carcinoma
|
6
|
59.7
| | | | |
Others
|
19
|
11.1
| | | | |
Histologic grade
| | | | | | |
Poorly differentiated or Undifferentiated
|
31
|
7.03
|
.869
| | | |
Unspecified
|
148
|
5.63
| | | | |
Liver metastases
| | | | | | |
Yes
|
80
|
5.1
|
.236
| | | |
No
|
99
|
7.7
| | | | |
Lung metastases
| | | | | | |
Yes
|
87
|
4.43
|
.005
| | | |
No
|
92
|
9.2
| | | | |
Bone metastases
| | | | | | |
Yes
|
74
|
5.33
|
.255
| | | |
No
|
105
|
6.43
| | | | |
Lymph node metastases
| | | | | | |
Yes
|
107
|
6.17
|
.658
| | | |
No
|
72
|
6.47
| | | | |
No. of metastatic organs
| | | |
1.927
|
1.147-3.237
|
.013
|
1
|
40
|
18.07
|
.028
| | | |
≥ 2
|
139
|
5.33
| | | | |
Radiotherapy
| | | | | | |
Yes
|
52
|
11.1
|
.105
| | | |
No
|
127
|
5.07
| | | | |
Chemotherapy
| | | |
3.211
|
2.009-5.132
|
< .001
|
Yes
|
118
|
9.2
|
< .001
| | | |
No
|
61
|
1.63
| | | | |
Albumin
| | | |
2.216
|
1.440-3.409
|
< .001
|
< 3.5 g/dl
|
66
|
2.77
|
< .001
| | | |
≥ 3.5 g/dl
|
113
|
11.1
| | | | |
Estimated creatinine clearance
| | | | | | |
< 60 ml/min
|
75
|
6.43
|
.806
| | | |
≥ 60 ml/min
|
74
|
6.17
| | | | |
Corrected Ca level
| | | |
4.421
|
1.529-12.784
|
.006
|
< 10.7 mg/dl
|
171
|
6.47
|
.006
| | | |
≥ 10.7 mg/dl
|
6
|
0.57
| | | | |
Lactate dehydrogenase
| | | | | | |
< 250 U/L
|
76
|
10.67
|
.001
| | | |
≥ 250 U/L
|
102
|
3.67
| | | | |
Na
| | | | | | |
< 135 mmol/l
|
55
|
2.07
|
< .001
| | | |
≥ 135 mmol/l
|
124
|
9.0
| | | | |
Cholesterol
| | | | | | |
< 150 mg/dl
|
56
|
4.07
|
.014
| | | |
≥ 150 mg/dl
|
110
|
9.2
| | | | |
Alkaline phosphatase
| | | | | | |
< 100 U/L
|
80
|
7.03
|
.569
| | | |
≥ 100 U/L
|
99
|
5.63
| | | | |
WBC count (× 103 cells/μL)
| | | | | | |
< 10.0
|
124
|
10.27
|
< .001
| | | |
> 10.0
|
55
|
3.23
| | | | |
Lymphocyte count
| | | | | | |
< 700/μL
|
17
|
2.67
|
.003
| | | |
≥ 700/μL
|
162
|
7.03
| | | | |
Hemoglobin level
| | | | | | |
< 11 g/dl
|
67
|
5.33
|
.091
| | | |
≥ 11 g/dl
|
112
|
7.73
| | | | |
Platelet count
| | | | | | |
< 150 × 109/L
|
33
|
4.87
|
.82
| | | |
≥ 150 × 109/L
|
146
|
6.43
| | | | |
- HR, hazard ratio; CI, confidence interval; WBC, white blood cell.