Figure 1

Domain organisation of representative WASP proteins. A colour key to the domain names and symbols is given on the right except for the WH1 domain and the poly-proline region (PPR) that are coloured in dark green and yellow, respectively. The abbreviations for the domains are: WH2, WASP homology 2 domain; WAID, WASP autoinhibitory domain. The phylogenetic tree on the left shows the schematic branching of some major taxa of the Dikarya fungi and, as single representative, Yarrowia lipolytica. For each branch, the domain organisation of one representative WASP homolog is shown on the right. The schematic tree has been created based on the most comprehensive phylogenetic analysis of yeast species [26]. Species abbreviations: Hs = Homo sapiens, Tv = Trichomonas vaginalis, Orn = Oreochromis niloticus, Sc = Saccharomyces cerevisiae, Wa = Wickerhamomyces anomalus, Deh = Debaryomyces hansenii, Yl = Yarrowia lipolytica, An = Aspergillus niger, Sp = Schizosaccharomyces pombe, Um = Ustilago maydis.