Sequence conservation of the WH2 domains of WASP family proteins. The sequence logos illustrate the sequence conservation within the multiple sequence alignments of the WH2 domains. Several of the WASP proteins as well as the vertebrate WHAMM homologs encode two WH2 domains in tandem that are shown separately here. The linker between the N-terminal helix part of the WH2 domain and the C-terminal LKKT motif are of variable length. To align all WH2 domains to each other, four to five gaps have been introduced into the linker of all but the WASP-WH2A and WASH alignments. The sequence logos are based on the following number of sequences: WASP-WH2A = 343; WASP-WH2B = 110; WAVE = 321; WASH = 141; WHAMM-WH2A = 63; WHAMM-WH2B = 69; WAML = 14; WAWH = 19.