Investigation of VSX1 sequence variants in South Indian patients with sporadic cases of keratoconus

BMC Research Notes

Table 2 Frequencies of VSX 1 gene variants in sporadic KTCN cases and healthy controls

VSX1 gene variations			Case		Control		Allelic p value	OR (95% CI)
VSX1 gene variations			n=117	%	n=108	%	Allelic p value	OR (95% CI)
(rs12480307) c.546A>G	Genotype	AA	74	63.2	76	70.4
		GA	36	30.8	28	25.9
		GG	7	6.0	4	3.7
	Allele	A	184	78.6	180	83.4	0.205	0.74 (0.44-1.21)
	Allele	G	50	21.4	36	16.6	0.205	0.74 (0.44-1.21)
(rs6138482) c.627+23G>A	Genotype	GG	88	75.2	67	62.0
		GA	26	22.2	40	37.0
		AA	3	2.6	1	0.9
	Allele	G	202	86.3	174	80.6	0.099	0.66 (0.38-1.12)
	Allele	A	32	13.7	42	19.4	0.099	0.66 (0.38-1.12)
(rs56157240) c.627+84T>A	Genotype	TT	59	50.4	58	53.7
		TA	49	41.9	43	39.8
		AA	9	7.7	7	6.5
	Allele	T	167	71.4	159	73.6	0.595	1.12 (0.72-1.73)
		A	67	28.6	57	26.4	0.595	1.12 (0.72-1.73)
IVS3-24C>T c.504-24C>T	Genotype	CC	110	94.0	101	93.5
		CT	7	6..0	7	6.5
		TT	0	0	0	0
	Allele	C	227	97	209	96.7	0.879	1.09 (0.32-3.69)
		T	7	3	7	3.3	0.879	1.09 (0.32-3.69)

OR-odds ratio, CI- confidence interval, p-value less than 0.05 was considered as significant.

ISSN: 1756-0500