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Table 2 Frequencies of VSX 1 gene variants in sporadic KTCN cases and healthy controls

From: Investigation of VSX1 sequence variants in South Indian patients with sporadic cases of keratoconus

VSX1 gene variations Case Control Allelic p value OR (95% CI)
n=117 % n=108 %
(rs12480307) c.546A>G Genotype AA 74 63.2 76 70.4   
GA 36 30.8 28 25.9
GG 7 6.0 4 3.7
Allele A 184 78.6 180 83.4 0.205 0.74 (0.44-1.21)
G 50 21.4 36 16.6
(rs6138482) c.627+23G>A Genotype GG 88 75.2 67 62.0   
GA 26 22.2 40 37.0
AA 3 2.6 1 0.9
Allele G 202 86.3 174 80.6 0.099 0.66 (0.38-1.12)
A 32 13.7 42 19.4
(rs56157240) c.627+84T>A Genotype TT 59 50.4 58 53.7   
  TA 49 41.9 43 39.8
  AA 9 7.7 7 6.5
Allele T 167 71.4 159 73.6 0.595 1.12 (0.72-1.73)
  A 67 28.6 57 26.4
IVS3-24C>T c.504-24C>T Genotype CC 110 94.0 101 93.5   
  CT 7 6..0 7 6.5
  TT 0 0 0 0
Allele C 227 97 209 96.7 0.879 1.09 (0.32-3.69)
  T 7 3 7 3.3
  1. OR-odds ratio, CI- confidence interval, p-value less than 0.05 was considered as significant.