Figure 3

Ingenuity pathway gene network analysis of incisor vs. molar expressed genes. The two most significant gene networks identified in the Ingenuity pathway analysis of our microarray data are shown. These networks (see Results for details) are centered on the NFκB complex (A) and the ERK1/2 kinases (B). Many of the key genes highlighted in these networks are members of the ontology groups that include receptors, ligands and interacting proteins, and two families of transcription factors: homeodomain (homeobox encoded) proteins and nuclear receptors. The networks are displayed graphically as nodes (genes/gene products) and edges (biological relationships between the nodes). Differentially expressed genes are shown in two colors, the intensity of the colors reflecting the degree of enrichment in molar (red) versus incisor (green) tooth buds. Nodes are displayed using various shapes representing the functional class of the gene product (flat oval: transcription factor; tall oval: transmembrane receptor or interacting protein; losange: enzyme; triangle: kinase; rectangle: G protein-coupled receptor; circle: other). Interactions are depicted by arrows ("acts on", with dashed arrows indicating "indirect" interactions) or straight lines (binding only).