Table 2 Overview of genes belonging to selected signaling pathways (FGF, TGFβ/BMP, Wnt, Hedgehog, Retinoic acid, Notch) or to the homeobox-containing superfamily, showing differential expression in mandibular molar or incisor
Pathway/Family | Gene names (fold change) | Number of genes | Differentially expressed in teeth | Not known to be differentially expressed in teeth | New genes in teeth | Total new genes and new differentially expressed genes |
|---|---|---|---|---|---|---|
FGF: molars | Fgf12 (2.24) | 1 | 0 | 1 | 0 | 1 |
FGF: incisors | Fgf22 (-1.41) | 1 | 0 | 0 | 1 | 1 |
TGFβ: molars | Thbs2 (1.77); Gdf7 (1.73); Bmpr1a (1.36); Ppp2r1b (1.35); Mapk1 (1.3); Smurf2 (1.25) | 6 | 0 | 2 | 4 | 6 |
TGFβ: incisors | Bmp5 (-3.20); Gdf6 (-2.00); Acvr1c (-1.59); Inhbe (-1.52); Nodal (-1.45) | 5 | 0 | 1 | 4 | 5 |
Wnt: molars | Sfrp1 (3.56); Sfrp2 (2.16); Plcb4 (1.66); Camk2d (1.48); Ccnd2 (1.44); Ppp2r1b (1.35); Cul1 (1.30); Ppp3cb | 8 | 0 | 1 | 7 | 8 |
Wnt: incisors | Sfrp4 (-12.38); Wnt 5a (-2.38); Cer1 (-1.64); Wnt9b (-1.51); Wnt1 (-1.45); Camk2a(-1.34); Ppp3r2 (-1.32) | 7 | 0 | 1 | 6 | 7 |
Hedgehog incisors | Ihh (-1.30); Btrc (1.26); Gas1 -(1.25) | 3 | 0 | 1 | 2 | 3 |
Retinoic acid: molars | Cyp1b1; Nr2f1 (3.59); Nr2f2 (2.69). Aldh7a1 (1.50) | 4 | 0 | 0 | 4 | 4 |
Retinoic acid: incisors | Cyp26c1 (-4.05); Cyp2c54 (-2.26); Rdh1 (-1.94); Cyp2c66 (-1.81); Cyp2a12 (-1.76); Rarres1 (-1.57); Rdh9 (-1.57); Ugt1a9 (-1.57); Aldh1b1 (-1.51); Rbp3 (-1.49); Pram1 (-1.43); Rarres2 (-1.35); Adh7 (-1.33); Cyp2b19 (-1.31); Rdh8 (-1.29) | 15 | 0 | 1 | 14 | 15 |
Notch: incisors | Rbpjkl (-2.12); predicted gene 5109 (-1.71); Dll1 (-1.37) | 3 | 0 | 0 | 3 | 3 |
Homeobox genes: molars | Barx1 (8.59); Six2 (4.81); Lhx6 (3.69); Shox2 (2.85); Dlx1 (2.81); Dbx2 (1.97); Six4 (1.95); Six1 (1.83); Lhx8 (1.64) | 9 | 6 | 2 | 1 | 3 |
Homeobox genes: incisors | Alx1 (-15.94 ) Alx3 (-8.36); Isl1 (-6.44 ) ; Irx4 (-5.31); Tlx1 (-2.83); Otx1 (-2.48) ; Hoxa11 (-1.92); Hoxd8 (-1.86); Hoxd3 (-1.84); Hoxd4 (-1.81); Obox5 (-1.76); Lbx2 (-1.74); Rhox6 (-1.72); Hoxd10 (-1.66); Rhox1 (-1.62); Lmx1b (-1.61); Hoxd11 (-1.60); Hoxd1 (-1.60); Nkx2-1 (-1.60);Hnf1b (-1.59); Hoxc6 (-1.58); Irx6 (-1.58); Sebox (-1.57); Hhex (-1.55); Lhx4 (-1.54); Rhox12 (-1.54); Rhox2a (-1.53); Hoxc4 (-1.52); Tlx2 (-1.47); Rhox7 (-1.46); Hoxa9 (-1.44); Hoxa2 (-1.41); Pdx1 (-1.40); Hoxb9 (-1.40); Esx1 (-1.39); Crx (-1.36) ; Hoxb7 (-1.36); Hoxa6 (-1.35); Arx (-1.33); Dux (-1.33); Lbxcor1 (-1.32); Gsx2 (-1.29); Hmx2 (-1.27); Hoxb2 (-1.27); Gbx1 (-1.26) | 45 | 2 | 1 | 42 | 43 |
Total | Â | 107 | 8 | 11 | 88 | 99 |