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Table 2 Overview of genes belonging to selected signaling pathways (FGF, TGFβ/BMP, Wnt, Hedgehog, Retinoic acid, Notch) or to the homeobox-containing superfamily, showing differential expression in mandibular molar or incisor

From: Molars and incisors: show your microarray IDs

Pathway/Family Gene names (fold change) Number of genes Differentially expressed in teeth Not known to be differentially expressed in teeth New genes in teeth Total new genes and new differentially expressed genes
FGF: molars Fgf12 (2.24) 1 0 1 0 1
FGF: incisors Fgf22 (-1.41) 1 0 0 1 1
TGFβ: molars Thbs2 (1.77); Gdf7 (1.73); Bmpr1a (1.36); Ppp2r1b (1.35); Mapk1 (1.3); Smurf2 (1.25) 6 0 2 4 6
TGFβ: incisors Bmp5 (-3.20); Gdf6 (-2.00); Acvr1c (-1.59); Inhbe (-1.52); Nodal (-1.45) 5 0 1 4 5
Wnt: molars Sfrp1 (3.56); Sfrp2 (2.16); Plcb4 (1.66); Camk2d (1.48); Ccnd2 (1.44); Ppp2r1b (1.35); Cul1 (1.30); Ppp3cb 8 0 1 7 8
Wnt: incisors Sfrp4 (-12.38); Wnt 5a (-2.38); Cer1 (-1.64); Wnt9b (-1.51); Wnt1 (-1.45); Camk2a(-1.34); Ppp3r2 (-1.32) 7 0 1 6 7
Hedgehog incisors Ihh (-1.30); Btrc (1.26); Gas1 -(1.25) 3 0 1 2 3
Retinoic acid: molars Cyp1b1; Nr2f1 (3.59); Nr2f2 (2.69). Aldh7a1 (1.50) 4 0 0 4 4
Retinoic acid: incisors Cyp26c1 (-4.05); Cyp2c54 (-2.26); Rdh1 (-1.94); Cyp2c66 (-1.81); Cyp2a12 (-1.76); Rarres1 (-1.57); Rdh9 (-1.57); Ugt1a9 (-1.57); Aldh1b1 (-1.51); Rbp3 (-1.49); Pram1 (-1.43); Rarres2 (-1.35); Adh7 (-1.33); Cyp2b19 (-1.31); Rdh8 (-1.29) 15 0 1 14 15
Notch: incisors Rbpjkl (-2.12); predicted gene 5109 (-1.71); Dll1 (-1.37) 3 0 0 3 3
Homeobox genes: molars Barx1 (8.59); Six2 (4.81); Lhx6 (3.69); Shox2 (2.85); Dlx1 (2.81); Dbx2 (1.97); Six4 (1.95); Six1 (1.83); Lhx8 (1.64) 9 6 2 1 3
Homeobox genes: incisors Alx1 (-15.94 ) Alx3 (-8.36); Isl1 (-6.44 ) ; Irx4 (-5.31); Tlx1 (-2.83); Otx1 (-2.48) ; Hoxa11 (-1.92); Hoxd8 (-1.86); Hoxd3 (-1.84); Hoxd4 (-1.81); Obox5 (-1.76); Lbx2 (-1.74); Rhox6 (-1.72); Hoxd10 (-1.66); Rhox1 (-1.62); Lmx1b (-1.61); Hoxd11 (-1.60); Hoxd1 (-1.60); Nkx2-1 (-1.60);Hnf1b (-1.59); Hoxc6 (-1.58); Irx6 (-1.58); Sebox (-1.57); Hhex (-1.55); Lhx4 (-1.54); Rhox12 (-1.54); Rhox2a (-1.53); Hoxc4 (-1.52); Tlx2 (-1.47); Rhox7 (-1.46); Hoxa9 (-1.44); Hoxa2 (-1.41); Pdx1 (-1.40); Hoxb9 (-1.40); Esx1 (-1.39); Crx (-1.36) ; Hoxb7 (-1.36); Hoxa6 (-1.35); Arx (-1.33); Dux (-1.33); Lbxcor1 (-1.32); Gsx2 (-1.29); Hmx2 (-1.27); Hoxb2 (-1.27); Gbx1 (-1.26) 45 2 1 42 43
Total   107 8 11 88 99
  1. Genes are listed as being enriched in expression in molar or incisor, with fold changes in expression in parentheses. Genes already known from the literature to be expressed in teeth appear in bold, and those for which a differential expression was reported for the two tooth types are underlined. Additional columns summarize the literature survey, scoring genes previously described as expressed in developing teeth ("Known in teeth"), as differentially expressed in both tooth types ("Known as differentially expressed"), or "new" (i.e. not described in the literature: right-most column).