Molars and incisors: show your microarray IDs

BMC Research Notes

Table 3 Overview of genes differentially expressed between lower (mandibular) and upper (maxillary) molars

A	Genes	Fold change	P-value	Known in teeth	Known as differentially expressed	References
Enriched in lower molars	Nefl	6.28	1.68E-08	No	No
	Ostn	4.12	6.22E-06	No	No
	Nkx2-3	3.97	5.32E-10	Yes	Yes	[69]
	Tnnt1	3.19	9.08E-08	No	No
	Chrna1	3.04	4.47E-06	No	No
	Nefm	3.01	1.54E-08	No	No
	Myf5	2.94	7.14E-09	No	No
	Klhl31	2.92	4.58E-08	No	No
	Plac8	2.91	4.68E-09	No	No
	Synpo2l	2.87	3.71E-08	No	No
Enriched in upper molars	Naalad2	-2.21	6.48E-09	No	No
	Kcnb2	-2.29	1.42E-06	No	No
	Itga8	-2.34	4.57E-08	No	No
	Atp6	-2.84	1.26E-07	No	No
	Alx1	-2.85	2.50E-08	No	No
	Gabrb2	-3.06	7.32E-09	No	No
	Ndst4	-3.48	4.21E-06	No	No
	Pla2g7	-3.99	1.34E-08	No	No
	Nmbr	-4.25	5.52E-10	No	No
	Cyp26c1	-5.04	1.74E-10	Yes	No	[63]
B
Enriched in lower molars	Dlx6	2.76	1.01E-07	Yes	No	[70]
	Gsc	2.21	1.31E-06	Yes	No	[71]
	Pitx1	2.19	6.09E-08	Yes	Yes	[19]
	Prkcq	2.15	6.71E-07	Yes	No	[61]
	Barx2	2.00	3.47E-07	Yes	No	[72]
	Lhx9	1.86	1.12E-06	No	No
	Nkx6-1	1.62	4.43E-08	No	No
	Lhx1	1.48	2.87E-06	No	No
	Msx3	1.43	8.33E-07	No	No
	Nkx2-1	1.40	1.84E-06	No	No
Enriched in upper molars	Gli1	-1.34	6.21E-07	Yes	No	[73]
	Dlx1	-1.36	2.18E-06	Yes	No	[71]
	Lhx8	-1.48	2.57E-06	Yes	No	[51]

As for Table 1, this table is organized in two sections showing: (A) The top ten genes showing highest expression in mandibular (lower) molars (positive values) or maxillary (upper) molars (negative values); (B) examples of genes known from the literature as being expressed in developing teeth, only a minority being described as differentially expressed in upper vs. lower molars ("Known as differentially expressed"), or not described in the literature. Among the top ten genes, only two were known to be expressed in developing teeth. For a complete list of differentially expressed genes (with fold changes > 2 or < -2), see Additional file 4.

ISSN: 1756-0500