Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours

Table 1 Type of testicular germ cell tumor in 39 probands ^# plus degree of relatedness to familial case(s) of TGCT

	Degree of relatedness to affected relative
Type of testicular germ cell tumor in the proband	1^st	2^nd	3^rd	>3^rd	Total
Seminoma, NOS	5	3	4	0	12
Embryonal carcinoma, NOS	1	3	1	1	6
Teratoma, benign	0	0	1	0	1
Teratocarcinoma	1	0	2	2	5
Choriocarcinoma combined with other germ cell elements	0	0	2	0	2
Yolk sac tumor	0	0	1	0	1
Germ cell tumor, nonseminomatous	0	0	1	0	1
Mixed germ cell tumor (mixed teratoma and seminoma)	1	1	0	0	2
Mixed germ cell tumor (mixed embryonal and seminoma)	3	1	2	0	6
Mixed germ cell tumor (mixed yolk sac and seminoma)	0	0	0	1	1
NSGCT (mixed yolk sac and teratoma, benign)	0	0	1	0	1

*First degree- parent, sib, child; second degree - aunt, uncle, grandparent, grandchild; third degree – cousin; more than third – second cousin. If more than one relative affected, only the closest degree of relatedness is included.
NSGCT – Non-seminoma germ cell tumor; NOS – not otherwise specified.
^#Family history could not be confirmed for two cases (seminoma and yolk sac tumor) and pathology could not be fully confirmed on a further two cases. These four cases were excluded from the table.

ISSN: 1756-0500