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Table 2 Set of knockouts and the corresponding chemical reactions used as case study 2

From: TNA4OptFlux – a software tool for the analysis of strain optimization strategies

Reaction Stoichiometric equation
Isocitrate lyase Isocitrate = > Succinate + Glyoxylate
Glycine cleavage (complex) Glycine + NAD+ + Tetrahydrofolate = > NH4+ + 5,10-Methylenetetrahydrofolate + NADH + CO2
Phosphoenolpyruvate carboxylase Oxaloacetate + Phosphate < = > Phosphoenol pyruvate + Bicarbonate
phosphoribosylglycinamide formyltransferase 2 5-phospho-ribosyl-glycineamide + Formate + ATP < = > 5'-phosphoribosyl-N-formylglycineamide + ADP + Phosphate + H+