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Table 2 Study characteristics - hip

From: Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis

Study, Year Patients lost to follow-up and/or excluded after randomization Dose of TXA Method of TXA administration Control Transfusion criteria Method of measuring blood loss Deep vein thrombosis screening method DVT prophylaxis
Benoni, 2000[29] 1 10 mg/kg at end of operation + again three hours later. IV S Clinical condition Swabs + drain Clinical exam. Klexane.
Benoni, 2001[33] 2 10 mg/kg - max = 1 gram over 5–10 minutes, immediately before operation started. IV S Clinical decision. Usually Hb < 80–100 g/L. Swabs + drain Clinical exam. Klexane.
Husted, 2003[25] 0 10 mg/kg for 10 minutes, 15 minutes prior to incision + 1 mg/kg/hr for 10 hours. IV S Hb < 25% + clinical symptoms. Drain + transfusions + swabs Clinical exam +/− ultrasound + follow-up 3 months post-op. Low molecular weight heparin.
Yamasaki, 2004[40] 0 1000 mg 5 minutes prior to operation. IV Non-TXA N/R Swabs + drain Clinical exam + ascending phlebography. None
Garneti, 2004[14] 0 10 mg/kg. IV S N/R Swabs + drain Belfast scan, duplex scan or venogram - fifth postoperative day. DTV stockings + foot pumps.
Lemay, 2004[34] 1 Test dose 1 mL. 10 mg/kg prior to surgery. 1 mg/kg/hr infusion until wound closure. IV S 90 g/L or 70 g/L – dependant on patient. Swabs + drain Clinical exam daily + ultrasound of both inferior limbs between post-op days 5–10 or earlier if symptoms present. Dalteparin.
Johansson, 2005[26] 19 15 mg/kg single injection. IV S Hb < 90 g/L Swabs + drain + Hb balance method. Clinical exam +/−ultrasound. Fragmin.
Niskanen, 2005[30] 1 Three doses of 10 mg/kg. 1st over 5–10 minutes immediately before operation. 2nd + 3rd, 8 hrs + 16 hours after operation IV S Hct 28% - 30% + clinical situation Swabs + drain Clinical exam +/− ultrasound. Dalteparin.
Claeys, 2007[32] 0 15 mg/kg. IV S Hb < 85 g/L or Hemocrit < 27%. Swabs + drain Clinical exam daily + ultrasound on tenth postoperative day. Fraxiparine.
Kazemi, 2010[8] 0 15 mg/kg slowly 5 minutes pre-operatively IV S Used allowable blood loss formula. Swabs + drain Clinical exam. Enoxaparin.
Malhotra, 2011[20] 0 15 mg/kg 15 minutes prior to surgery. IV S Reduction in Hb exceeding 25% + clinical symptoms. Swabs + drain Colour ultrasound on tenth post-op day. Low molecular weight heparin + elastic leg dressing.
McConnell, 2011[38] 0 10 mg/kg bolus at start of surgery. IV Non-TXA N/R Change in hemocrit method. N/R Stockings + early mobilization + aspirin
Imai, 2012[39]   1 g 1) 10 minutes prior to skin closure 2) and again 2 hours later. 1 g 3) 10 minutes before surgery 4) and again 6 hours later. IV Non-TXA N/R Change in hemocrit method. Whole body CT on 7th postoperative day. Stockings + enoxaparin
  1. DVT – deep venous thrombosis, C – Control, TXA – tranexamic acid, S – saline, IV – intravenously, N/R – not reported.