From: Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis
Study, Year | Number of patients TXA/C | Gender distribution % male TXA /C | Mean age TXA,C (SD or range) | Mean weight (kg) - TXA, C (SD or Range) | TBL - TXA,C (mL) (SD) | P Value | Number of patients requiring allogeneic transfusions (TXA, C) | P Value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TXA | C | TXA | X | TXA | C | TXA | X | TCA | C | TXA | C | |||
Hiippala, 1995[27] | 15 | 13 | 13 | 23 | 70 (56–82) | 70 (63–78) | 72 (10) | 74 (10) | 847 (356) | 1549 (574) | <0.001 | 10 | 12 | N/R |
Benoni, 1996[17] | 43 | 43 | 30 | 23 | 76 (7) | 74 (7) | 73 (14) | 78 (16) | 730 (280) | 1410 (480) | <0.001 | 8 | 24 | <0.001 |
Hiippala, 1997[12] | 39 | 38 | 10 | 21 | 70 (7) | 69 (5) | 74 (13) | 78 (12) | 689 (289) | 1509 (643) | < 0.0001 | 17 | 34 | <0.0001 |
Jansen, 1999[2] | 21 | 21 | 24 | 14 | 70.7 (62–80) | 71.0 (64–84) | 78.8 (11.0) | 75.8 (12.4) | 678 (352) | 1419 (607) | <0.001 | 2 | 13 | <0.001 |
Engel, 2001[42] | 12 | 12 | 50 | 50 | 71 (9) | 66 (11) | 83 (12) | 80 (13) | 800 (295–1050) | 865 (245–1370) | N/R | 0 | 3 | N/R |
Ellis, 2001[36] | 10 | 10 | 40 | 30 | 71 (5) | 72 (8) | 80 (12) | 77 (15) | N/R | N/R | N/R | 1 | 7 | N/R |
Tanaka, 2001[41] ** | 73 | 26 | 29, 32, 30 | 65 (59–70), , 65 (60–71), 65 (59–69) | 65 (58–70) | 60 (45–70), 60 (45–70), 60 (40–76) | 61 (45 to 76) | 720.4* (187.2) | 1470 (264.8) | N/R | 17, 16, 14 | 26 | N/R | |
Veien, 2002[3] | 15 | 15 | 73 | 93 | 70.5 (9.5) | 69.5 (9.0) | 78.7 (12.3) | 74.3 (14.1) | 409.7 (174.9) | 761.7 (313.1) | <0.001 | 0 | 2 | N/R |
Good, 2003[18] | 27 | 24 | 33 | 25 | 72 (46–83) | 72 (50–84) | 79 (13) | 80 (13) | 1045◊ (368.7 ) | 1426◊ (620.9 ) | <0.001 | 3 | 14 | <0.001 |
Zohar, 2004[35] *** | 60 | 20 | 30, 20, 40 | 35 | 73 (8), 69 (7), 69 (10) | 73 (7) | 78 (12), 75 (13), 77 (13) | 75 (12) | N/R | N/R | N/R | 3, 2, 4 | 12 | N/R |
Orpen, 2006[5] | 15 | 14 | 47 | 79 | 73 (95% CI 70–78) | 69 (95% CI 63–74) | 83 (95% CI 69–112) | 77 (95% CI 58–96) | 660 (317.6)† | 726 (333.0) † | 0.55 | 1 | 3 | N/R |
Camarasa, 2006[31] | 35 | 60 | 26 | 20 | 73 (61–84) | 72 (52–85) | N/R | 1095 (473) | 1784 (660) | N/R | N/R | N/R | ||
Álvarez, 2007[6] | 46 | 49 | 15 | 20 | 71 (9) | 72 (7) | N/R | 1301 (621) | 1744 (804) | 0.002 | N/R | N/R | ||
Molloy, 2007[19] | 50 | 50 | N/R | N/R | N/R | N/R | N/R | 1225 (499) | 1415 (416) | 0.041 | 5 | 11 | 0.79 | |
Kakar 2009[4]‡ | 12 | 12 | 25 | 33 | 62.4 (9.4), | 66.2 (4.8) | 67.9 (10.8) | 63.4 (7.2) | 160 (87) | 270 (88) | <0.05 | N/R | N/R | |
Wong, 2010[11] □ | 64 | 35 | 19, 42 □ | 37 | 67 (11.9), 63.9 (10.6) | 68.4 (10.4) | 82.0 (15.6), 81.8 (14.7) | 87.9 (19.2) | 1295 (353.7), 1208 (376.0) | 1610 (378.6) | 0.0001 | 1, 0 | 2 | 0.083 |
Ishida, 2011[43] | 50 | 50 | 12 | 12 | 73.3 (5.0) | 73.5 (6.1) | 59.7 (9.0) | 59.7 (10.1) | N/R | N/R | 0 | 1 | N/R | |
Sa-ngasoongsong, 2011[24] | 24 | 24 | 78 | 82 | 69.0 (8.2) | 69.2 (7.6) | N/R | N/R | 206.3 (115.4) | 385.1 (145.2) | <0.0001° | 1 | 8 | 0.023 |
Roy, 2012[37] | 25 | 25 | 40 | 36 | 66.04 (7.15) | 66.56 (8.03) | N/R | N/R | **** 109.6 ± 71.54 + 401 ± 82.44 | **** 194 ± 79.66 + 870 ± 201.04 | N/R | 2 | 7 | Not Significant |