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Table 4 Patient characteristics - hip

From: Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis

Study, Year Number of patients TXA/C Gender distribution % male TXA /C Mean age TXA,C (SD or range) Mean weight (kg) – TXA, C (SD or Range) TBL – TXA,C (mL) (SD) P Value Patient requiring allogeneic transfusions (TXA, C) P Value
  TXA C TXA C TXA C TXA C TXA C   TXA C  
Ekbäck, 2000[28] 20 20 45 55 66.4 (9.0) 65.6 (8.8) 81.1 (13) 76.8 (13) 1130 (400) 1770 (523) <0.001 5 5 N/R
Benoni, 2000[29] 20 19 30 58 69.5 (10) 68 (10) 76 (14), 77 (11) 990 (210 ), 950 (162.5) N/R 45 79 0.05
Benoni, 2001[33] 18 20 50 50 66 (9.5) 68 (9.4) 79 (16) 78 (17) 759 (275.8†) 996 (398†) 0.03 22 40 0.2
Husted, 2003[25] 20 20 35 30 65 67 N/R 814 (1323.8†) 1231 (1692.7†) 0.001 10 35 0.04
Yamasaki, 2004[41] 20 20 95 90 55.5 (14.2) 61.2 (6.9) 52.6 (11.5) 54.5 (8.7) 1350 (477) 1667 (401) <0.05 0 0 N/R
Garneti, 2004[14] 25 25 N/R 69.6 (11.99) 67.6 (11.4) N/R 1443 (809) 1340 (665) 0.822 64 56 N/R
Lemay, 2004[34] 20 19 60 68 59.7 (10.3) 53.6 (12.8) 80.1 (15.7) 74.7 (14.1) 1308 (462) 1469 (405) N/R 0 42 0.0012
Johansson, 2005[26] 47 53 53 53 69 (7) 69 (7) 81 (16) 78 (13) 969 (434) 1324 (577) <0.001 17 43 0.009
Niskanen, 2005[30] 19 20 32 35 66 (9.1) 65 (8.2) 80 (19) 82 (14) 792 (390.1†) 1102 (485.2 †) 0.03 26 40 0.3
Claeys, 2007[32] 20 20 25 35 73 (8) 68 (11) 76 (15) 72 (16) 801 (244) 1038 (289) 0.013 5 30 <0.05
Kazemi, 2010[8] 32 32 72 63 46.6 (16.2) 45.4 (17.2) 72.1 (10.4), 69.9 (11.1) 1024 (544) 1399 (587) 0.024 N/R N/R
Malhotra, 2011[20] 25 25 40 48 52.6 (39–72) 54.7 (40–71) 80.2 (58–100) 81.9 (62–98) 410 (300–510) – range 615 (515–750) –range <0.5 24 72 N/R
McConnell, 2011[38] 22 22 32 41 N/R N/R N/R N/R 930 (399†) 1200 (469†) 0.02 0 0 N/R
Imai, 2012[39] * 24, 20, 25, 26 22 17, 20, 16, 15 23 64.4 (49–74), 62.2 (50–85), 63.3 (47–80), 63.3 (48–81) 60.2 (54–72) 55.9 (44–86), 54.1 (40–76), 54.1 (41–70), 53.8 (44–73) 56.3 (47–80) 649, 566, 388, 418** 1026** N/R 0 0 N/R
  1. Sum of perioperative and drain medians7, † - Calculated from 95% CI, C – Control group, TXA – Tranexamic group, SD – Standard Deviation, DVT – deep venous thrombosis, N/R – not reported. *Patients received 1 g TXA 10 minutes prior to skin closure, 10 minutes prior to skin closure and 6 hrs later, 10 minutes prior to surgery, 10 minutes prior to surgery and 6 hrs later, respectively. ** Intra-op + post-op.