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Table 2 Patient demographics and overall response to treatment

From: Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn’s Disease

  AGE years SEX CONDITION DURATION years* CONCOMITANT THERAPIES OVERALL RESPONSE TO TREATMENT ^      NOTES
1 35 F PD 1.5 Azathioprine 1yr, prednisolone Cleared Relapsed on stopping at 12 weeks
2 27 M PD, MCD 4 Azathioprine 1yr, Prednisolone, Asacol Two areas healed rest improved prior to exiting Dropped out due to flare of Crohn’s
3 60 F PG 33 Azathioprine 2yr, Predfoam, Asacol Improved Dropped out - intolerable pain from ointment
4 65 F PD 10 Nil Improved Relapsed on stopping at 12 weeks
5 33 M GC 12 Nil Improved initially, worsened during extension Relapsed on stopping at 12 weeks
6 37 F GC 5 Prednisolone Improved Less frequent and severe swelling.
7 20 M PD 3 Azathioprine 5yr, Methotrexate Improved Dropped out - severe flare of systemic disease
8 12 M GC 5 Nil Moderate improvement Relapsed on stopping at 12 weeks
9 32 M MCD 4 Azathioprine 2yr No change  
10 66 M PD 1.5 Nil Initial improvement Relapsed on stopping at 12 weeks
11 42 M PD 17 Nil Improved  
12 16 M GC 13 Nil Mild improvement Relapsed on stopping at 12 weeks
13 56 F PD 15 Asacol, Predfoam Moderate improvement Relapsed on stopping at 12 weeks
14 29 F PD 1.5 Nil No change  
15 35 M PD 0.75 Nil Pronounced improvement Relapsed on stopping at 12 weeks
16 63 F PG, PD 6 Nil Pronounced improvement Systemic disease flared week 9
17 33 M PD 5 Nil Skin healed at 8 weeks but pain continued Exited trial at week 8
18 15 M GC 10 Nil Moderate improvement of lip swelling Fewer mouth ulcers, relapsed
19 30 M PD, MCD 25 Nil Cleared  
20 38 F PPG 1.5 Prednisolone, methotrexate, infliximab Pronounced improvement Relapsed on stopping at 12 weeks
  1. * Duration of diagnosis of cutaneous Crohn’s disease; ^ Physicians Global Assessment; PD perineal disease; GC granulomatous chelitis; MCD mixed connective tissue disease; PPG peristomal pyoderma gangrenosum.