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Figure 1 | BMC Research Notes

Figure 1

From: ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response

Figure 1

General health, neurological reflex, nociception, and motor coordination/learning in Grin1Rgsc174/ Grin1+mice. Grin1Rgsc174/Grin1+ mice showed significantly decreased body weight (A) and an increased latency to fall in the wire hang test (D) compared to wild-type mice. There were no significant differences between the genotypes regarding body temperature (B), grip strength (C), or latency to the first hind-paw response in the hot plate test (E). (F) The latency to fall of Grin1Rgsc174/Grin1+ mice was significantly increased in the rotarod test. (G) Body weight was negatively correlated with rotarod latencies (averaged latency on the 1st day) in Grin1Rgsc174/Grin1+ and wild-type mice. In the gait analysis, Grin1Rgsc174/Grin1+ mice showed a significant decrease in the stance width of the hind paws (P). No significant differences were detected in any other of the following indices of front (H-M) or hind (N-S) paw the gait analysis: percentage of stride duration in swing, brake, and propel (H, N), percentage of stance duration in brake and propel (I, O), stance width (cm) of front paws (J), stride length (cm) (K, Q), step angle (degree) (K, Q), and paw angle (degree) (L, R). The p values indicate the effect of genotype in one-way ANOVA.

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