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Table 4 Comprehensive behavioral test battery of Grin1Rgsc174/Grin1+mice

From: ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response

Test Age (w) Number of samples Figure/Table
Light–dark transition test 10 C, 11; M, 10 Figure 3
Open field test 10 C, 11; M, 10 Figure 2
Hot plate test 11 C, 11; M, 10 Figure 1
Elevated plus maze test 11 C, 11; M, 9 Figure 3
General health test 12 C, 11; M, 10 Figure 1
Social interaction test in novel environment 12 C, 5; M, 3* Figure 4
Rotarod test 12 C, 11; M, 10 Figure 1
Crawley’s three-chamber social approach test 12-13 C, 11; M, 10 Figure 4
Acoustic startle response test 14 C, 11; M, 10 Figure 7
Prepulse inhibition test 14 C, 10; M, 7 Table 2
Porsolt forced swim test 15 C, 11; M, 10 Figure 5
Gait analysis 27-28 C, 10; M, 7 Figure 1
Eight-arm radial maze test 37-40 C, 10; M, 7 Figure 6
Contextual and cued fear conditioning Test 46 C, 11; M, 10 Figure 6
Tail suspension test 46 C, 11; M, 10 Table 2
Social interaction test in familiar environment 48-49 C, 5; M, 3* Figure 4
  1. C: Controls.
  2. M: Mutants.
  3. * Number of pairs.