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Table 1 Functional similarities between HHV-8 and human confirmed by DASH

From: Domain analysis of symbionts and hosts (DASH) in a genome-wide survey of pathogenic human viruses

HHV-8

Human

Function

PfamA accession

Function type

Original study

Gene

Protein gi

E-value

Dom. Cov.

Protein gi

E-value

Dom. Cov.

ORF9

139472809

2.12e-141

0.99

14250670

4.95e-134

0.97

DNA polymerase

PF00136, PF03104

M

Russo et al.

ORF61

139472880

6.11e-124

1.00

194389080

7.11e-211

1.00

Ribonucleotide reductase, large chain

PF02867, PF00317

M

Russo et al.

ORF70

139472812

3.29e-109

1.00

4507751

2.69e-113

1.00

Thymidylate synthase

PF00303

M

Russo et al.

ORF60

139472853

2.23e-87

0.97

4557845

1.79e-116

1.00

Ribonucleotide reductase, small chain

PF00268

M

Russo et al.

ORF75

139472887

1.76369e-42

0.99

38197270

9.58835e-88

1.00

CobB/CobQ-like glutamine amidotransferase, AIR synthase

PF13507, PF02769, PF12818

M

Russo et al.

ORF2

139472863

5.06e-22

0.98

4503323

6.19e-25

0.99

Dihydrofolate reductase

PF00186

M

Russo et al.

ORF72

139472885

3.41e-21

0.98

4502613

3.71e-39

0.99

Cyclin

PF00134, PF09080

I

Russo et al.

K9

139472878

2.00e-16

0.74

119604110

2.26e-59

0.99

Interferon regulatory factor

PF10401, PF00605

I

Russo et al.

ORF46

139472838

6.58e-15

0.97

194387970

8.97e-20

0.97

Uracil DNA glycosylase

PF03167

M

Russo et al.

ORF74

139472805

4.12e-14

1.00

197692661

5.57e-94

1.00

7 transmembrane receptor

PF00001

M

Russo et al.

K4

139472814

1.18e-13

0.95

2905626

3.40e-15

0.95

Small cytokine, interleukin-8 like

PF00048

I

Russo et al.

K6

139472866

1.88e-13

0.94

2905626

3.40e-15

0.95

Small cytokine, interleukin-8 like

PF00048

I

Russo et al.

ORF56

139472847

1.07e-12

0.97

119625077

1.42e-07

0.99

Herpesviridae UL52/UL70 DNA primase

PF03121

M

Russo et al.

ORF71/K13

139472802

3.17e-12

0.93

194386924

1.55e-18

0.99

CASP8 and FADD-like apoptosis regulator

PF01335

I

Russo et al.

K2

139472811

8.35e-11

0.96

23835

1.70e-57

1.00

Interleukin-6/G-CSF/MGF family

PF00489

I

Russo et al.

ORF54

139472845

9.88e-08

0.78

158256462

7.73e-40

0.99

dUTPase

PF00692

M

Russo et al.

K5

139472815

6.46686e-07

1.00

221043596

1.14442e-06

1.00

Membrane-Associated RING-CH (MARCH)

PF12906

I

Bartee et al.

K3

139472864

2.58674e-06

1.00

221043596

1.14442e-06

1.00

Membrane-Associated RING-CH (MARCH)

PF12906

I

Bartee et al.

K4.1

139472813

3.06e-06

0.91

2905626

3.40e-15

0.95

Small cytokine, interleukin-8 like

PF00048

I

Neipel et al.

ORF16

139472817

3.64e-05

0.95

10279702

3.71e-24

1.00

Apoptosis regulator, Bcl-2 family

PF00452

I

Russo et al.

vIRF-3/K10.5/K10.6

139472850

1.13e-03

0.68

119604110

2.26e-59

0.99

Interferon regulatory factor

PF10401

I

Russo et al.

KCP/ORF4

139472860

1.29e-02

0.91

80478231

1.42e-04

1.00

Complement control protein

PF00084

I

Russo et al.

vIRF-2/K11/K11.1

139472851

6.35e-01

0.68

119604110

2.26e-59

0.99

Interferon regulatory factor

PF10401

I

Russo et al.

vIRF-4/K10/K10.1

139472849

4.94e+00

0.76

119604110

2.26e-59

0.99

Interferon regulatory factor

PF10401

I

Russo et al.

  1. Abbreviation: (Dom Cov.) Domain coverage—fraction of Pfam HMM model coverage by viral/human sequence alignment. Function types: (I) Immunomodulatory, and (M) metabolic.