Table 1 Basic clinicopathological data for hepatitis B patients included
Characteristics | Training cohort | Verification |
|---|---|---|
(n = 213) | cohort (n = 211) | |
Age at biopsy in years, mean ± SD | 44.4 ± 11.8 | 45.6 ± 11.4 |
Male, n (%) | 179 (84) | 175 (83) |
Biopsy | ||
Necroinflammation score, mean ± SD | ||
Periportal inflammation | 1.0 ± 0.8 | 0.9 ± 0.8 |
Confluence necrosis | 0.3 ± 1.0 | 0.2 ± 0.8 |
Focal inflammation | 1.9 ± 0.7 | 2.0 ± 0.7 |
Portal inflammation | 2.2 ± 1.0 | 2.2 ± 0.9 |
ISHAK fibrosis score, n (%) | ||
0 | 1 (1) | 1 (1) |
1 | 28 (13) | 28 (13) |
2 | 32 (15) | 32 (15) |
3 | 70 (33) | 71 (34) |
4 | 21 (10) | 21 (10) |
5 | 46 (22) | 45 (21) |
6 | 15 (7) | 13 (6) |
HBeAg-positive, n (%) | 109 (51) | 91 (43) |
Biochemistry, mean ± SD | ||
AST (IU/mL) | 91.3 ± 83.6 | 94.9 ± 100.1 |
ALT (IU/mL) | 170.1 ± 173.8 | 166.2 ± 177.9 |
AST/ALT | 0.6 ± 0.3 | 0.6 ± 0.3 |
AFP (ng/mL) | 10.5 ± 22.2 | 20.4 ± 82.0 |
Bilirubin (mg/dL) | 1.0 ± 0.7 | 1.0 ± 0.4 |
GGT (IU/L) | 69.0 ± 77.0 | 60.1 ± 57.3 |
Albumin (g/dL) | 4.6 ± 0.3 | 4.5 ± 0.4 |
Platelet (×103/mm3) | 188.2 ± 54.2 | 189.2 ± 49.4 |
Prothrombin time prolongation (sec) | 1.0 ± 0.6 | 1.0 ± 0.8 |
White blood cell (×103/mm3) | 5.7 ± 1.7 | 5.5 ± 1.6 |
Hemoglobin (g/dL) | 15.1 ± 1.4 | 15.2 ± 1.3 |
Alpha-1 globulin (g/dL) | 0.2 ± 0.1 | 0.2 ± 0.0 |
Alpha-2 globulin (g/dL) | 0.8 ± 0.2 | 0.8 ± 0.1 |
Beta globulin (g/dL) | 0.8 ± 0.1 | 0.7 ± 0.1 |
Gamma globulin (g/dL) | 1.5 ± 0.4 | 1.4 ± 0.4 |
Albumin/Globulin | 1.5 ± 0.3 | 1.5 ± 0.3 |