Table 2 Univariate and multivariate analysis for factors associated with liver fibrosis

Age at biopsy

0.035 (0.018, 0.052)

< 0.001

0.018 (0.001, 0.036)

0.044

Male

0.046 (-0.597, 0.506)

0.870

HBeAg-positive

-0.496 (-0.943, -0.048)

0.030

AST (IU/mL)

0.001 (-0.001, 0.004)

0.363

ALT (IU/mL)

0.000 (-0.001, 0.001)

0.802

AST/ALT

1.881 (1.199, 2.563)

< 0.001

1.085 (0.368, 1.803)

0.003

AFP (ng/mL)

0.012 (0.001, 0.023)

0.026

Bilirubin (mg/dL)

0.142 (-0.168, 0.452)

0.367

GGT (IU/L)

0.006 (0.002, 0.009)

0.003

Albumin (g/dL)

-1.440 (-2.839, -0.042)

0.044

Platelet (×10³/mm³)

-0.012 (-0.015, -0.009)

< 0.001

-0.009 (-0.013, -0.005)

< 0.001

Prothrombin time prolongation (sec)

0.781 (0.404, 1.157)

< 0.001

0.449 (0.098, 0.800)

0.012

White blood cell (×10³/mm³)

0.049 (-0.093, 0.192)

0.495

Hemoglobin (g/dL)

0.053 (-0.125, 0.231)

0.558

Alpha-1 globulin (g/dL)

-0.898 (-2.683, 0.886)

0.322

Alpha-2 globulin (g/dL)

-0.505 (-1.746, 0.736)

0.423

Beta globulin (g/dL)

-0.808 (-2.160, 0.545)

0.240

Gamma globulin (g/dL)

0.214 (-0.327, 0.754)

0.436

Albumin/Globulin

-0.422 (-1.180, 0.335)

0.273