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Table 3 Performance of six fibrosis score for evaluation of liver fibrosis and cirrhosis in patients with chronic hepatitis B

From: Development of a non-invasive fibrosis test for chronic hepatitis B patients and comparison with other unpatented scores

Non-invasive index

AUC (95% CI)

Difference between areas (95% CI)*

P*

Prominent fibrosis

Ā Ā Ā 

HB-F (training)

0.810 (0.751, 0.861)

Ā Ā 

HB-F (verification)

0.797 (0.737, 0.849)

Ā Ā 

FIB-4

0.772 (0.709, 0.826)

0.0255 (-0.0236, 0.0746)

0.3087

Fibroindex

0.767 (0.704, 0.822)

0.0301 (-0.0298, 0.0899)

0.3251

ARPI

0.753 (0.689, 0.810)

0.0439 (-0.0302, 0.1180)

0.2454

AAR

0.630 (0.561, 0.696)

0.1670 (0.0947, 0.2390)

< 0.0001

FI

0.724 (0.659, 0.784)

0.0728 (0.0093, 0.1360)

0.0246

Cirrhosis

Ā Ā Ā 

HB-F (training)

0.799 (0.739, 0.851)

Ā Ā 

HB-F (verification)

0.757 (0.694, 0813)

Ā Ā 

FIB-4

0.727 (0.662, 0.786)

0.0297 (-0.0223, 0.0818)

0.2624

Fibroindex

0.722 (0.656, 0.781)

0.0351 (-0.0320, 0.1020)

0.3054

ARPI

0.698 (0.631, 0.759)

0.0589 (-0.0244, 0.1400)

0.1556

AAR

0.636 (0.568, 0.701)

0.1210 (0.0470, 0.1950)

0.0013

FI

0.717 (0.651, 0.777)

0.0403 (-0.0283, 0.1090)

0.2497

  1. *Comparison between the AUC of HB-F (verification cohort) and those of the other scoring methods.