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Figure 2 | BMC Research Notes

Figure 2

From: Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence

Figure 2

Methamphetamine-induced DA release is inhibited by bupropion, methylphenidate and MDPV. The corresponding IC50 values are shown in Table 1. DA release was induced with 10 μM methamphetamine (100% release) and blocked with different concentration of the inhibitors bupropion, methylphenidate or MDPV. Baseline (0% release) was defined as the radioactivity remaining in the cells treated with bupropion, methylphenidate, or MDPV alone. The data are expressed as mean ± SEM of 3–4 independent experiments.

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