Methamphetamine-induced DA release is inhibited by bupropion, methylphenidate and MDPV. The corresponding IC50 values are shown in Table 1. DA release was induced with 10 μM methamphetamine (100% release) and blocked with different concentration of the inhibitors bupropion, methylphenidate or MDPV. Baseline (0% release) was defined as the radioactivity remaining in the cells treated with bupropion, methylphenidate, or MDPV alone. The data are expressed as mean ± SEM of 3–4 independent experiments.