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Table 1 Potencies of drugs to block DA uptake or methamphetamine-induced DA release

From: Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence

  DA uptake Methamphetamine-induced DA release
  IC50 (μM) (95% CI) IC50 (μM) (95% CI)
Methamphetamine 1.05 (0.7-1.5) -
Bupropion 1.76 (1.1-2.8) 14.2 (9.7-21)
Methylphenidate 0.14 (0.1-0.2) 1.67 (0.7-4.0)
MDPV 0.031(0.03-0.04) 0.28 (0.1-0.6)
  1. Values are means of 3–4 independent experiments and 95% confidence intervals (CI).