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Table 1 Primary mediastinal synovial sarcoma patients presenting with unresectable/ advanced disease

From: Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature

Author Age/ Gender Presentation Histologic subtype Treatment Outcome
de Zwaan C, et al. Neth Heart J. 2007;15(6):226–8. 19 / M S.O.B, congested neck veins, edema, cardiac tamponade M Patient refused therapy DWD at 3 months.
Korula A, et al. Singapore Med J. 2009 Jan;50(1):e26-8. 49 / M S.O.B, chest pain, Pericardial effusion NA Supportive care only. Patient refused CTX NA
Suster S, et al. Am J Surg Pathol. 2005 May;29(5):569–78. 13 / M Weakness, S.O.B, right pleural effusion M EBRT only DWD at 6 months after developing liver metastases.
23 / F Weakness, chest pain B Partial excision followed by EBRT NA
48 / M Chest pain M EBRT only NA
54 / F Left shoulder pain B Partial excision followed by EBRT Local progression and epidural metastasis at one year. DWD.
83 / M S.O.B, pleural effusion M EBRT only NA
Arafah M, et al. Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):384–7. 30 / M S.O.B, cough, weight loss M Palliative CTX (Ifosfamide+Doxorubicin) Regression of mediastinal mass after 3 cycles. AWD at 6 months
Hung JJ, et al. Ann Thorac Surg. 2008 Jun;85(6):2120–2. 24 / M Chest pain, S.O.B, back pain, cough, fevers M Partial excision followed by EBRT PD five weeks after EBRT (local+lung metastases). PD with bone metastases following treatment with Ifosfamide and epirubicin. DWD 6 months after diagnosis.
Paquette M, et al. J Thorac Oncol. 2010 Jun;5(6):898–906. NA NA NA EBRT only PR following EBRT. Local progression at 32 months. DWD at 38 months.
NA NA NA CTX (Ifosfamide+Doxorubicin) PD during CTX. DWD at 5 months
Trupiano JK, et al. Ann Thorac Surg. 2002 Feb;73(2):628–30. 30 / F Incidental on imaging B Partial resection and combination CTX DWD at 10 months
Nakagawa Y, et al. Nihon Kokyuki Gakkai Zasshi. 2010 Oct;48(10):734–8. 65 / M Cough with bloody sputum NA CTX, EBRT, and hyperthermia PD following CTX, EBRT, and hyperthermia. DWD at 20 months.
Lee HJ, et al. J Lung Cancer 2008;7(1):29-33 44 / M Cough, SOB, chest pain M Partial resection following PR to neoadjuvant Adriamycin+ Dacarbazine Adjuvant EBRT (59.4 Gy in 33 fractions). Developed bilateral lung metastases three months after finishing EBRT.
Kaira K, et al. J Comput Assist Tomogr. 2008 Mar-Apr;32(2):238-41 64 / F Back pain, dysphagia NA EBRT, CTX upon PD (Ifosfamide+Doxorubicin), re-irradiation and hyperthermia Symptomatic improvement after EBRT, response to CTX, DWD at 24 months
58 / M Right sided back pain NA EBRT and hyperthermia, CTX (Ifosfamide+Doxorubicin) upon PD, second line CTX (Gemcitabine + Docetaxel), third line carboplatin Initial response after EBRT, hyperthermia, and first line CTX, DWD at 19 months
Current case 32 / F S.O.B, lower limb edema, pericardial effusion M CTX (Ifosfamide +Doxorubicin) PD after CTX, refused further therapy. AWD at 11 months
  1. S.O.B shortness of breath, NA not available, M monophasic, B biphasic, CTX chemotherapy, EBRT external beam radiotherapy, DWD died with disease, AWD alive with disease, PD progression of disease, PR partial response.