Table 1 Primary mediastinal synovial sarcoma patients presenting with unresectable/ advanced disease
From: Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature
Author | Age/ Gender | Presentation | Histologic subtype | Treatment | Outcome |
|---|---|---|---|---|---|
de Zwaan C, et al. Neth Heart J. 2007;15(6):226–8. | 19 / M | S.O.B, congested neck veins, edema, cardiac tamponade | M | Patient refused therapy | DWD at 3 months. |
Korula A, et al. Singapore Med J. 2009 Jan;50(1):e26-8. | 49 / M | S.O.B, chest pain, Pericardial effusion | NA | Supportive care only. Patient refused CTX | NA |
Suster S, et al. Am J Surg Pathol. 2005 May;29(5):569–78. | 13 / M | Weakness, S.O.B, right pleural effusion | M | EBRT only | DWD at 6 months after developing liver metastases. |
23 / F | Weakness, chest pain | B | Partial excision followed by EBRT | NA | |
48 / M | Chest pain | M | EBRT only | NA | |
54 / F | Left shoulder pain | B | Partial excision followed by EBRT | Local progression and epidural metastasis at one year. DWD. | |
83 / M | S.O.B, pleural effusion | M | EBRT only | NA | |
Arafah M, et al. Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):384–7. | 30 / M | S.O.B, cough, weight loss | M | Palliative CTX (Ifosfamide+Doxorubicin) | Regression of mediastinal mass after 3 cycles. AWD at 6 months |
Hung JJ, et al. Ann Thorac Surg. 2008 Jun;85(6):2120–2. | 24 / M | Chest pain, S.O.B, back pain, cough, fevers | M | Partial excision followed by EBRT | PD five weeks after EBRT (local+lung metastases). PD with bone metastases following treatment with Ifosfamide and epirubicin. DWD 6 months after diagnosis. |
Paquette M, et al. J Thorac Oncol. 2010 Jun;5(6):898–906. | NA | NA | NA | EBRT only | PR following EBRT. Local progression at 32 months. DWD at 38 months. |
NA | NA | NA | CTX (Ifosfamide+Doxorubicin) | PD during CTX. DWD at 5 months | |
Trupiano JK, et al. Ann Thorac Surg. 2002 Feb;73(2):628–30. | 30 / F | Incidental on imaging | B | Partial resection and combination CTX | DWD at 10 months |
Nakagawa Y, et al. Nihon Kokyuki Gakkai Zasshi. 2010 Oct;48(10):734–8. | 65 / M | Cough with bloody sputum | NA | CTX, EBRT, and hyperthermia | PD following CTX, EBRT, and hyperthermia. DWD at 20 months. |
Lee HJ, et al. J Lung Cancer 2008;7(1):29-33 | 44 / M | Cough, SOB, chest pain | M | Partial resection following PR to neoadjuvant Adriamycin+ Dacarbazine | Adjuvant EBRT (59.4 Gy in 33 fractions). Developed bilateral lung metastases three months after finishing EBRT. |
Kaira K, et al. J Comput Assist Tomogr. 2008 Mar-Apr;32(2):238-41 | 64 / F | Back pain, dysphagia | NA | EBRT, CTX upon PD (Ifosfamide+Doxorubicin), re-irradiation and hyperthermia | Symptomatic improvement after EBRT, response to CTX, DWD at 24 months |
58 / M | Right sided back pain | NA | EBRT and hyperthermia, CTX (Ifosfamide+Doxorubicin) upon PD, second line CTX (Gemcitabine + Docetaxel), third line carboplatin | Initial response after EBRT, hyperthermia, and first line CTX, DWD at 19 months | |
Current case | 32 / F | S.O.B, lower limb edema, pericardial effusion | M | CTX (Ifosfamide +Doxorubicin) | PD after CTX, refused further therapy. AWD at 11 months |