TY - JOUR AU - Indra, Mochamad Rasjad AU - Karyono, Satuman AU - Ratnawati, Retty AU - Malik, Safarina G. PY - 2013 DA - 2013/07/16 TI - Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs) JO - BMC Research Notes SP - 275 VL - 6 IS - 1 AB - High concentrations of plasma leptin and the release of pro-inflammatory cytokines in leptin-resistance in obesity have been reported to trigger endothelial dysfunction. The objective of this study was to elucidate the role of quercetin in modulating leptin-induced inflammation as assessed by the levels of Ob-Ra expression, ERK1/2 phosphorylation, NF-kappa B activation and TNF-alpha secretion in umbilical vein endothelial cells (HUVECs) in vitro. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-6-275 DO - 10.1186/1756-0500-6-275 ID - Indra2013 ER -