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Table 1 Simulations predict that nitrogen depletion affects both Cln3 and Cln1

From: The effective application of a discrete transition model to explore cell-cycle regulation in yeast

Hypotheses

Possible nitrogen depletion targets

Results of simulations

Point of cell-cycle arrest

Wild-type

Stable Cln1

Hypothesis 1

Cln3, Cln3/Cdk

G1 and G2

G1 and G2

Hypothesis 2

Cln3, Cln3/Cdk, SIC1 transcription

G1

G1

Hypothesis 3

Cln3, Cln3/Cdk, Cln1, Cln1/Cdk

G1

G1 and G2

  1. Cells at different steps in the normal cell-cycle simulation were “shifted” to simulations in which Nitrogen was depleted.