Table 2 Comparison of patients with LMNA gene mutation and stroke
From: Cardioembolic stroke related to limb-girdle muscular dystrophy 1B
Author | Age of stroke | Stroke signs | Stroke location | Arrhythmia during all follow-up | Pacemaker insertion and age | Phenotype | Mutation of LMNA gene |
|---|---|---|---|---|---|---|---|
Onishi et al., 2002 [11] | 45 | Right hemiplegia | N/A | AF, AVB, VPC | Pacemaker, 45 | AD-EDMD | p.Ser303Pro (c.907 T>C) |
Boriani et al., 2003 [4] | 26 | Hemiplegia | N/A | AF, AFL, AVB | VVI, 30 | AD-EDMD | p.Arg386Lys (c.1157 G>A) |
57 and 70 | N/A | N/A | AF, AVB, SAB | VVI, 55 | AD-EDMD | p.Arg527Pro (c.1580 G>C) | |
43 and 44 | Ataxia | Cerebellum | AF, AVB | VVI, 41 | AD-EDMD | p.Arg377Leu (c.1130 G>T) | |
Liang et al., 2007 [12] | 45 | Conscious loss | Pons | VPC, VT, VF | nil | AD-EDMD | p.Trp520Gly (c.1558 T>G) |
Redondo-Vergé et al., 2011 [13] | 25 | Aphasia, right hemiparesis | Left MCA | AF, AVB | ICD, 25 | AD-EDMD | p.Arg89Leu (c.266 G>T) |
Tanaka et al., 2012 [14] | 12 | Dysarthria, left hemiparesis | Right MCA | AF | nil | AD-EDMD | N/A |
Present case | 39 | Aphasia, right hemiplegia | Left MCA | AF, RBBB, AVB | VVI, 37 | LGMD1B | c.IVS2+1 G>A (c.513+1 G>A) |