Table 2 Paired comparison of clinical parameters between baseline and week 2 in different outcomes and treatment groups

1270 (146–2480)

167 (41–485)

<0.001

1270 (211–2480)

184 (41–485)

<0.001

1197 (146–2247)

112.5 (66–190)

0.068

1523 (211–2480)

184 (80–435)

0.011

870 (146–2247)

133.5 (41–485)

0.002

9.2 (2.1–33.1)

6.8 (1.8–43.2)

0.728

7.7 (2.1–16.8)

4.8 (1.8–21.3)

0.309

20.6 (11.9–33.1)

29.1 (17.8–43.2)

0.068

8.6 (2.1–20.4)

8.0 (1.9–25.3)

0.515

10.25 (2.2–33.1)

5.15 (1.8–43.2)

1.000

0.68 (0.39–1.46)

0.94 (0.37–3.79)

0.002

0.71 (0.47–1.34)

1.0 (0.37–1.81)

0.019

0.48 (0.39–1.46)

0.92 (0.72–3.79)

0.068

0.71 (0.47–1.05)

0.90 (0.59–1.49)

0.051

0.63 (0.39–1.46)

1.03 (0.37–3.79)

0.021

116 (53–254)

89 (18–241)

0.005

116 (53–183)

77 (37–241)

0.042

194.5 (54–254)

90.5 (18–129)

0.068

116 (73–201)

89 (37–147)

0.044

127 (53–254)

79 (18–241)

0.050

111.1 (52.9–156.7)

98.3 (18.9–134.5)

0.003

110.1 (52.9–131.1)

82.9 (36.8–134.5)

0.028

138.2 (59.8–156.7)

101.8 (18.9–126.4)

0.068

112 (77.8–148)

98.3 (40.9–126.4)

0.066

110.6 (5.29–56.7)

86.9 (18.9–134.5)

0.028

1.6 (1.3–3.5)

1.4 (1.0–4.2)

0.066

1.5 (1.3–2.3)

1.3 (1.0–2.8)

0.062

3.3 (2.6–3.5)

2.75 (2.2–4.2)

0.577

1.5 (1.3–3.1)

1.7 (1.1–2.8)

0.440

1.6 (1.4–3.5)

1.35 (1.0–4.2)

0.058

65.7 (4.1–650.7)

305.5 (6.2–2802)

0.013

49.4 (4.1–477.2)

459.6 (35.4–2802)

0.005

109.5 (27.9–650.7)

36.3 (6.2–66.3)

0.180

27.9 (4.2–238.3)

191.9 (66.3–1462.5)

0.046

162.1 (4.1–650.7)

459.6 (6.2–2802)

0.139

8.04 (4.3–9.68)

4.19 (3.07–5.89)

<0.001

8.16 (5.22–5.06)

4.2 (3.07–5.89)

0.001

5.06 (4.3–8.2)

3.64 (3.31–3.96)

0.180

8.04 (4.97–9.47)

3.96 (3.07–5.10)

0.018

8.04 (4.30–9.68)

4.20 (3.13–5.89)

0.005

20 (13–37)

19 (11–49)

0.283

19 (13–28)

17 (11–32)

0.166

31.5 (26–.7)

30 (26–49)

0.655

19 (14–31)

20 (11–32)

0.674

20 (13–37)

18 (11–49)

0.469