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Table 1 Demographic and clinical data of patients with Mild Cognitive Impairment (MCI) and B12 deficiency compared with patients with MCI and normal vitamin B12 levels

From: Do MCI patients with vitamin B12 deficiency have distinctive cognitive deficits?

  MCI vitamin B12 deficiency (n=15) MCI normal vitamin B12 (n=45) P- value
Age, years [mean ± SD (range)] 74.9±7.6 74.9±6.9 1.00
Sex, female/male (n) 7/8 22/23 1.00
Formal education, years (mean ± SD) 6.7±4.6 7.4±4.8 0.66
Vitamin B12 level, pg/mL (mean ± SD) 148.4±42.7 496.9±218.9 <0.001*
Duration of cognitive complaints (mean ± SD) 1.2±1.0 3.4±3.0 <0.001*
Depressive symptoms, geriatric depression scale (mean ± SD) 3.6±1.5 4.1±2.9 0.59
Drugs with possible effect on cognition (n) 0 5 0.32
Response to vitamin B12 therapy, Yes/No/Unknown (n) 0/14/1 NA  
  1. Student’s t-test, Fisher’s exact test; *Statistically significant (p< 0.05), NA not applicable