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Table 4 Allele frequencies of the IL10 polymorphisms according to the Crohn’s disease phenotypes

From: Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease

    rs1800896    rs1800871*   
    AlleleG     Allele T   
  N n (%) OR P B P value n (%) OR P B P value
    [99.83 CI]     [99.83 CI]   
• Age at diagnosis          
A1 12 16 (66.7) 4.32 0.006 0.001 6 (25) 0.54 1.000 0.260
    [1.0022 – 8.62]     [0.07 - 2.59]   
A2 + A3 79 50 (31.6)     60 (38)    
• Behavior          
B1 62 42 (33.9) 0.68 1.000 0.316 47 (37.9) 1.4 1.000 0.401
    [0.23 - 2.05]     [0.46 - 4.58]   
B2 + B3 28 24 (42.9)     17 (30.4)    
P 40 30 (37.5) 1.07 1.000 0.877 48 (60) 7.77 < 0.0001 < 0.0001
    [0.38 - 2.96]     [2.53 - 26.90]   
  1. A1 ≤ 16 years, A2 17–40 years, A3 > 40 years, B1 Non-stricturing, non-penetrating, B2 Stricturing, B3 Penetrating, P Perianal disease modifier.
  2. N Number of patients, n (%) Number of alleles (percent), PB Bonferroni adjustment.
  3. *SNPs rs1800871 and rs1800872 were in 100% linkage disequilibrium.