Case–control association analysis of Dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males

Table 2 Allele and genotype frequencies of polymorphisms in DRD1, 3, 4 and their association status with alcohol dependence

SNPs	Genotypes			χ²(P)	Alleles		χ²(P)	OR (95% CI)	Power (G%)
D1 -48A > G	AA	AG	GG		A	G
Cases	0.14	0.49	0.37	7.65 (0.02)	0.38	0.62	3.96 (0.04)	1.77 (1.01-3.10)	76%
Controls	0.29	0.46	0.25	7.65 (0.02)	0.52	0.48	3.96 (0.04)
D3 Ser9Gly	CC	CT	TT		C	T
Cases	0.29	0.62	0.09	5.48 (0.07)	0.60	0.40	0.51 (0.47)	1.22 (0.7-2.15)	5%
Controls	0.30	0.50	0.20	5.48 (0.07)	0.55	0.45	0.51 (0.47)	1.22 (0.7-2.15)	5%
D4 120 Ins/Del	Ins/Ins	Ins/Del	Del/Del		Ins	Del
Cases	0.45	0.49	0.06	11.4 (0.00)	0.72	0.28	6.14 (0.01)	2.10 (1.17- 3.79)	86%
Controls	0.39	0.31	0.30	11.4 (0.00)	0.55	0.45	6.14 (0.01)	2.10 (1.17- 3.79)	86%

ISSN: 1756-0500