Figure 4
Network showing interactions between proteins encoded by genes differentially expressed after stimulation of Caco-2 BBE cell monolayers with IL-8. This network includes only differentially expressed genes that encode for proteins interacting with other proteins. Up-regulated genes are shown in shades of red and down-regulated genes in shades of blue; the intensity reflecting the fold-change. Note that the genes encoding the most connected proteins in the central part of the network (CREBBP, EP300, PPARD and HDAC1) were all up-regulated; these genes encode transcriptional regulators involved in lipid metabolism and cell differentiation. The network illustrates the core transcriptome changes modulating downstream processes including cell migration, signalling and differentiation.