Immunoglobulin A nephropathy with massive paramesangial deposits caused by anti-vascular endothelial growth factor therapy for metastatic rectal cancer: a case report and review of the literature

Table 3 Biopsy-documented cases with glomerular disease by bevacizumab

Reference	Age (years)/gender	Onset	Proteinuria	Hematuria	LM	IF	EM	Follow-up
4	59/M	9 mo	3.4 g/gCr	ND	Glomerular TMA	ND	FPE	Proteinuria decreased
4	74/M	3 mo	2.7 g/gCr	ND	Glomerular TMA	ND	FPE	Proteinuria decreased
4	56/M	7 mo	0.16 g/day	ND	Glomerular TMA	ND	Focal FPE	Dead shortly thereafter
4	62/M	3 mo	0.5 g/dl	+	Glomerular TMA	IgA, MES	Fibrin, SEn and MES	Proteinuria resolved
4	61/M	5 mo	4.6 g/day	ND	Glomerular TMA	ND	Focal podocyte injuries	ND
4	59/F	9 mo	0.8 g/day	ND	Glomerular TMA	IgA, MES	EDDs, SEn and focally MES	Persistent proteinuria
5	70/M	2 w	6.0 g/gCr	ND	Glomerular TMA	No	ND	Proteinuria decreased
9	59/M	15 mo	6.9 g/day	−	Glomerular TMA	IgA, MES and capillary	EDDs, sparsely SEn	Proteinuria decreased
10	ND/ND	ND	Nephrotic	ND	Cryo-GN	ND	ND	ND
11	ND/F	ND	Nephrotic	ND	Collapsing GP	ND	ND	ND
12	69/F	3 mo	3.6 g/day	−	Glomerular TMA + collapsing GP	IgA, capillary	SEn widening without EDDs	Proteinuria decreased
13	71/M	1 mo	9.6 g/day	ND	Focal PGN	C3 and IgM, MES and capillary	EDDs, sparsely SEn	Proteinuria decreased
14	ND/M	3 mo	3.4 g/gCr	ND	Glomerular TMA	ND	ND	ND
14	ND/ND	1 mo	3.2 g/gCr	ND	Glomerular TMA	ND	ND	ND
Present case	64/M	14 mo	3.5 g/day	+	MES PGN + TMA	IgA, MES and capillary	EDDs, MES and SEn	Proteinuria resolved

Foot notes of Table 3.
Onset means the duration form the start of bevacizumab to the appearance of urinary abnormalities.
M, male, F, female, LM, light microscopy, Cr, serum creatinine, IgA, immunoglobulin A, IgM, immunoglobulin M, C3, serum complement component 3, IF, immunofluorescence, EM, electron microscopy, TMA, thrombotic microangiopathy, MES, mesangial, SEn, subendothelial, Cryo-GN, cryoglobulinemic glomerulonephritis, GP, glomerulopathy, PGN, proliferative glomerulonephritis, FPE, foot process effacement, EDDs, electron dense deposits, ND, not documented, mo, month(s), w, week(s).

ISSN: 1756-0500