Skip to main content

Table 3 Biopsy-documented cases with glomerular disease by bevacizumab

From: Immunoglobulin A nephropathy with massive paramesangial deposits caused by anti-vascular endothelial growth factor therapy for metastatic rectal cancer: a case report and review of the literature

Reference Age (years)/gender Onset Proteinuria Hematuria LM IF EM Follow-up
4 59/M 9 mo 3.4 g/gCr ND Glomerular TMA ND FPE Proteinuria decreased
4 74/M 3 mo 2.7 g/gCr ND Glomerular TMA ND FPE Proteinuria decreased
4 56/M 7 mo 0.16 g/day ND Glomerular TMA ND Focal FPE Dead shortly thereafter
4 62/M 3 mo 0.5 g/dl + Glomerular TMA IgA, MES Fibrin, SEn and MES Proteinuria resolved
4 61/M 5 mo 4.6 g/day ND Glomerular TMA ND Focal podocyte injuries ND
4 59/F 9 mo 0.8 g/day ND Glomerular TMA IgA, MES EDDs, SEn and focally MES Persistent proteinuria
5 70/M 2 w 6.0 g/gCr ND Glomerular TMA No ND Proteinuria decreased
9 59/M 15 mo 6.9 g/day Glomerular TMA IgA, MES and capillary EDDs, sparsely SEn Proteinuria decreased
10 ND/ND ND Nephrotic ND Cryo-GN ND ND ND
11 ND/F ND Nephrotic ND Collapsing GP ND ND ND
12 69/F 3 mo 3.6 g/day Glomerular TMA + collapsing GP IgA, capillary SEn widening without EDDs Proteinuria decreased
13 71/M 1 mo 9.6 g/day ND Focal PGN C3 and IgM, MES and capillary EDDs, sparsely SEn Proteinuria decreased
14 ND/M 3 mo 3.4 g/gCr ND Glomerular TMA ND ND ND
14 ND/ND 1 mo 3.2 g/gCr ND Glomerular TMA ND ND ND
Present case 64/M 14 mo 3.5 g/day + MES PGN + TMA IgA, MES and capillary EDDs, MES and SEn Proteinuria resolved
  1. Foot notes of Table 3.
  2. Onset means the duration form the start of bevacizumab to the appearance of urinary abnormalities.
  3. M, male, F, female, LM, light microscopy, Cr, serum creatinine, IgA, immunoglobulin A, IgM, immunoglobulin M, C3, serum complement component 3, IF, immunofluorescence, EM, electron microscopy, TMA, thrombotic microangiopathy, MES, mesangial, SEn, subendothelial, Cryo-GN, cryoglobulinemic glomerulonephritis, GP, glomerulopathy, PGN, proliferative glomerulonephritis, FPE, foot process effacement, EDDs, electron dense deposits, ND, not documented, mo, month(s), w, week(s).