Skip to main content

Table 2 Association of peptic ulcer and use of other medicines among patients taking low-dose aspirin

From: Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers

  Case without ulcer Case with ulcer   Adjusted OR
Medicine n = 212 (%) n = 14 (%) OR (95% CI)* (95% CI)**
Anticoagulanta 19 (9.0) 4 (28.6) 4.06 (1.16 − 14.21) 5.88 (1.19 − 28.99)
Other antiplateletb 49 (23.1) 1 (7.1) 0.26 (0.03 − 2.01) 0.20 (0.02 − 1.83)
PPIc 89 (42.0) 2 (14.3) 0.23 (0.05 − 1.05) 0.13 (0.02 − 0.73)
H2RAd 36 (17.0) 1 (7.1) 0.38 (0.05 − 2.97) 0.35 (0.04 − 3.20)
Ca-blockere 67 (31.6) 4 (28.6) 0.87 (0.26 − 2.86) 1.27 (0.32 − 5.14)
ARBf 99 (46.7) 5 (35.7) 0.63 (0.21 − 1.96) 0.45 (0.12 − 1.65)
ACE inhibitorg 17 (8.0) 1 (7.1) 0.88 (0.11 − 7.16) 0.39 (0.05 − 4.34)
HMG-Co A redactase inhibitorh 94 (44.3) 6 (42.9) 0.94 (0.32 − 2.81) 2.09 (0.53 − 8.29)
NSAIDi 9 (4.3) 2 (14.3) 3.76 (0.73 − 19.36) 6.48 (0.75 − 56.41)
  1. OR, odds ratio; CI, confidence interval; PPI, proton pump inhibitor; H2RA, H2-receptor antagonist; ARB, AT1-receptor blocker; ACE, angiotensin-converting enzyme; HMG-Co A, 3-hydroxy-3-methyglutaryl coenzyme A, NSAID, non-steroidal anti-inflammatory drug.
  2. *Univariate analysis; ** Multivariate analysis adjusted for age and sex.
  3. aWarfarin 1 − 5 mg/day, bTiclopidine 100 or 200 mg/day, clopidogrel 75 mg/day, cilostazol 200 mg/day, cOmeprazole 10 or 20 mg/day, lansoprazole 15 or 30 mg/day, rabeprazole 10 mg/day, dFamotidine 10 or 20 or 40 mg/day, ranitidine 150 mg/day, roxatidine 150 mg/day, lafutidine 10 mg/day, eNifedipine 20 or 40 mg/day, amlodipine 2.5 or 5 mg/day, fCandesartan 4 or 8 mg/day, telmisartan 40 mg/day, olmesartan 20 mg/day, gImidapril 5 mg/day, hPravastatin 10 mg/day, atorvastatin 10 mg/day, iLoxoprofen 60 or 120 or 180 mg/day, selecoxib 100 mg/day, naproxen 300 mg/day.