Figure 2From: Metastatic melanoma in an esophagus demonstrating Barrett esophagus with high grade dysplasiaHistological and immunohistochemical findings. a) Barrett esophagus with high grade dysplasia present in the patient’s resection material (H&E, 100X). b) Second tumor nodule present within the mucosa and submucosa with distinct histologic features including c) large epithelioid cells with atypical nuclei with prominent nucleoli and frequent mitotic activity (H&E, 40X; H&E, 400X respectively). Immunohistochemical testing demonstrated the second tumor was positive for d) S-100, e) HMB-45 and f) Melan-A (each 40X).Back to article page