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Table 3 Comparison of current study cohort and other human milk fed cohorts

From: Human milk feeding supports adequate growth in infants ≤ 1250 grams birth weight

  Current study human milk + HMF 60*(n = 104) Human milk + HMF 40(n = 71) Human milk + HMF 100(n = 67) Bovine HMF or formula(n = 69) p-value
Birth weight, g 913 ± 182 909 ± 193 945 ± 202 922 ± 197 0.67
Birth length, cm 34.4 ± 2.6 34.9 ± 3.2 35.2 ± 3.1 35.0 ± 2.9 0.16
Birth head circumference, cm 24.2 ± 1.8 24.6 ± 1.9 24.6 ± 2.1 24.7 ± 1.6 0.35
Gestational age, wks 27.6 ± 2.0 27.1 ± 2.3 27.2 ± 2.2 27.3 ± 2.0 0.70
APGAR 5 minute 7 ± 2 8 ± 1 7 ± 2 7 ± 2 0.06
Male/Female, n (%) 49/55 (47/53) 25/46 (35/65) 32/35 (48/52) 36/33 (52/48) 0.21
Race: White, n (%) 28 (27) 37 (52) 33 (49) 34 (49) 0.001
   Black 40 (38) 17 (24) 20 (30) 10 (14)  
   Hispanic 24 (23) 15 (21) 13 (19) 22 (32)  
   Other 12 (12) 2 (3) 1 (2) 2 (3)  
Antenatal steroids, n (%) 77 (74) 51 (72) 56 (83) 53 (77) 0.39
Weight gain (g/kg/d) 24.8 ± 5.4 14.6 ± 4.5 14.0 ± 2.9 16.0 ± 7.8 <0.001
Length (cm/wk) 0.99 ± 0.23 0.93 ± 0.53 0.86 ± 0.44 0.93 ± 0.35 0.008
Head circumference (cm/wk) 0.72 ± 0.14 0.72 ± 0.22 0.71 ± 0.22 0.74 ± 0.22 0.84
Days to full feeds 18.2 ± 10.6 24.4 ± 12.7 26.5 ± 18.0 25.0 ± 13.5 <0.001
Day of life feeds initiated 3.3 ± 2.9 5.6 ± 6.6 4.3 ± 3.9 4.7 ± 4.8 0.56
Day of life feeds fortified 13.0 ± 8.3 14.1 ± 9.0 21.0 ± 14.9 18.4 ± 9.2 <0.001
TPN days 13 (10, 19)§ 20 (11,33) 20 (13,34) 22 (13,34) <0.001
% of human milk that was mother’s own milk 65.7 ± 40.3 70.6 ± 40.9 67.5 ± 37.2 N/A 0.046
  1. *mother’s own milk or donor human milk fortified with donor human milk derived fortifier at 60 ml/kg/d, Sullivan et. al, J Peds, 2010, Mean ± SD, §Median (25th, 75th percentile).