Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis

Table 3 Modelling results of both PLS-DA and TP predictive models before and after peak selection

Data	No. of spectra	No. of PLS comp	R2 (XPLS-DA)%	R2 (XTP)%	R2(y)%	% MCCR (DIVA)	SR limit	No. of selected peaks
C/S	88	5	70.6	19.7	97.8	80	0.41	10 (26%)
C/S^a	88	4	91.1	48.6	87.8

No. of spectra: 19 individuals in 3–5 replicates; R2 (XPLS-DA): 70.6% of total variance in X is explained in the PLS-DA model; R2 (XTP): 19.7% of total variance in X is explained in the TP model; R2(y): 97.8% of total variance in the response variable. y. is explained in both models; MCCR: mean correct classification rate; No. of selected peaks with percentage of total peak selection in brackets; C/S^a: modelling results after reduction of subset to only include the selected peaks.

ISSN: 1756-0500