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Table 1 Average release of the proinflammatory cytokines IL-1α, IL-8, TNFα (pg/ml) and LDH (measured by optical absorbance at 490 nm) from RHE 24 hours after topical treatment with S. epidermidis , P. acnes and S. aureus at different concentrations

From: The role of the skin barrier in modulating the effects of common skin microbial species on the inflammation, differentiation and proliferation status of epidermal keratinocytes

  Untreated control 1×107CFU 1×108CFU 1×109CFU
S. epidermidis  
[IL-1α] released 100 ± 3.5 116 ± 111.2 143.6 ± 156.8 186.8 ± 215.8
[IL-8] released 100 ± 18.4 151.7 ± 248.8 118.9 ± 156 193.4 ± 239.5*
[TNFα] released 100 ± 0.6 124.4 ± 35.6 138 ± 77.1 151.8 ± 80.7
LDH absorbance 100 ± 0.03 83.6 ± 63.2 82.6 ± 62.9 88.6 ± 58.2
P. acnes  
[IL-1α] released 100 ± 8.28 123.1 ± 100.3 122 ± 91 133.4 ± 112.1
[IL-8] released 100 ± 42.08 120.7 ± 129.6 109.5 ± 97.3 107.1 ± 84.9
[TNFα] released 100 ± 1.6 162.6 ± 158.1 115.7 ± 126.1 88.6 ± 113.6
LDH absorbance 100 ± 0.04 100.2 ± 148.4 108.8 ± 161.6 102.1 ± 142.8
S. aureus  
[IL-1α] released 100 ± 2.3 157.6 ± 303.8 1062.1 ± 3556.2 1251.7 ± 3735.6
[IL-8] released 100 ± 12.1 60.4 ± 27.7 93.1 ± 95.1 73 ± 2.6
LDH absorbance 100 ± 0.1 273.3 ± 357.5 505.2 ± 1002 666.4 ± 1321
  1. Results are expressed as percentage of the untreated control.
  2. *Single asterisk indicate statistically significant differences (P < 0.05) versus the untreated control.