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Table 2 Average expression of the RHE differentiation markers FLG, TG1, CLD, OCCL and the proliferation marker PCNA (measured as % expression of untreated control) 24 hours after topical treatment with S. epidermidis, P. acnes and S. aureus at different concentrations

From: The role of the skin barrier in modulating the effects of common skin microbial species on the inflammation, differentiation and proliferation status of epidermal keratinocytes

  Untreated control 1×107CFU 1×108CFU 1×109CFU
S. epidermidis     
FLG 100 ± 21.1 105 ± 50.5 113 ± 60 99 ± 37.4
TG1 100 ± 11 95 ± 30.7 95 ± 33.5 92 ± 25.8
CLD 100 ± 29.2 142 ± 68.3 161 ± 105.2* 123 ± 53.5
OCCL 100 ± 17.2 84 ± 30.9 95 ± 35.4 113 ± 63.8
PCNA 100 ± 25.3 129 ± 36.2 120 ± 39.2 135 ± 34*
P. acnes     
FLG 100 ± 28 110 ± 26.5 101 ± 42 99 ± 31.4
TG1 100 ± 26.9 125 ± 74.7 84 ± 29.9 77 ± 34.6
CLD 100 ± 36.5 90 ± 35.7 71 ± 32.1* 84 ± 31.6
OCCL 100 ± 33.4 112 ± 72.9 81 ± 40.5 97 ± 42.6
PCNA 100 ± 18.6 102 ± 49.4 132 ± 108.2 140 ± 93.9
S. aureus   1×10 3 CFU 1×10 5 CFU 1×10 7 CFU
FLG 100 ± 19.3 121 ± 32.6 107 ± 20.5 141 ± 45.9
TG1 100 ± 12 179 ± 65.8 112 ± 31.7 114 ± 34.3
CLD 100 ± 22.4 107 ± 25.3 126 ± 30.2 141 ± 43.8*
OCCL 100 ± 31.9 139 ± 67.7 141 ± 43.9 143 ± 45.7*
PCNA 100 ± 18 104 ± 22.6 98 ± 14.3 97 ± 48
  1. *Single asterisk indicate statistically significant differences (P < 0.05) versus the untreated control.