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Table 2 Average expression of the RHE differentiation markers FLG, TG1, CLD, OCCL and the proliferation marker PCNA (measured as % expression of untreated control) 24 hours after topical treatment with S. epidermidis, P. acnes and S. aureus at different concentrations

From: The role of the skin barrier in modulating the effects of common skin microbial species on the inflammation, differentiation and proliferation status of epidermal keratinocytes

 

Untreated control

1×107CFU

1×108CFU

1×109CFU

S. epidermidis

    

FLG

100 ± 21.1

105 ± 50.5

113 ± 60

99 ± 37.4

TG1

100 ± 11

95 ± 30.7

95 ± 33.5

92 ± 25.8

CLD

100 ± 29.2

142 ± 68.3

161 ± 105.2*

123 ± 53.5

OCCL

100 ± 17.2

84 ± 30.9

95 ± 35.4

113 ± 63.8

PCNA

100 ± 25.3

129 ± 36.2

120 ± 39.2

135 ± 34*

P. acnes

    

FLG

100 ± 28

110 ± 26.5

101 ± 42

99 ± 31.4

TG1

100 ± 26.9

125 ± 74.7

84 ± 29.9

77 ± 34.6

CLD

100 ± 36.5

90 ± 35.7

71 ± 32.1*

84 ± 31.6

OCCL

100 ± 33.4

112 ± 72.9

81 ± 40.5

97 ± 42.6

PCNA

100 ± 18.6

102 ± 49.4

132 ± 108.2

140 ± 93.9

S. aureus

 

1×10 3 CFU

1×10 5 CFU

1×10 7 CFU

FLG

100 ± 19.3

121 ± 32.6

107 ± 20.5

141 ± 45.9

TG1

100 ± 12

179 ± 65.8

112 ± 31.7

114 ± 34.3

CLD

100 ± 22.4

107 ± 25.3

126 ± 30.2

141 ± 43.8*

OCCL

100 ± 31.9

139 ± 67.7

141 ± 43.9

143 ± 45.7*

PCNA

100 ± 18

104 ± 22.6

98 ± 14.3

97 ± 48

  1. *Single asterisk indicate statistically significant differences (P < 0.05) versus the untreated control.