Figure 3

Thigmotaxis in young adult mice following nicotine administration. Nicotine (0.5 mg/kg) was administered for 5 consecutive days to a/a mice (a), and A^vy/a mice (b). For graphical presentation, thigmotaxis was calculated as $1-\frac{\mathit{\text{distance}}\mathit{\text{traveled}}\mathit{\text{outside}}\mathit{\text{center}}\mathit{\text{of}}\mathit{\text{apparatus}}}{\mathit{\text{total}}\mathit{\text{distance}}\mathit{\text{traveled}}}$. Data are presented as mean ± SE; n = 5–8 per group. * p < 0.05 significantly different from saline-matched controls.