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Table 3 Allele frequencies of the four studied pharmacogenetic variants in Cyprus and comparison with other populations

From: Genetic polymorphisms in warfarin and tacrolimus-related genes VKORC1, CYP2C9 and CYP3A5 in the Greek-Cypriot population

Population group No of tested chromosomes VKORC1-1639A CYP2C9*2 CYP2C9*3 CYP3A5*3 Reference
Greek-Cypriots 296 53.38% 16.20% 11.15% 94.26% This study
Nicosia 106 62.26% 18.87% 9.43% 95.28%
Limassol 52 44.23% 19.23% 11.54% 96.15%
Ammochostos 60 51.67% 15.00% 15.00% 93.33%
Larnaka 28 50.00% 14.29% 7.14% 92.86%
Pafos 32 50.00% 9.38% 9.38% 90.63%
Kerynia 18 44.44% 11.11% 16.67% 94.44%  
Caucasians 1362 37.81%     [21]
  (P < 0.001)     
3484   14.00% 6.40%   [12]
   (P = 0.296) (P = 0.002)   
284     95.50% [12]
      (P = 0.526)  
Africans 736 10.05%     [21]
  (P < 0.001)     
1376   2.20% 1.80%   [12]
   (P < 0.0001) (P < 0.001)   
1330     31.80% [12]
      (P < 0.001)  
Eastern Asians 1282 91.03%     [21]
  (P < 0.001)     
13284   <0.1% 3.30%   [12]
   (P < 0.001) (P < 0.001)   
7658     76.10% [12]
      (P < 0.001)  
Hellenes from Greece 656 44.40%     [22]
  (P = 0.010)     
566   12.90% 8.13% 94.35% [17]
    (P = 0.183) (P = 0.144) (P = 0.957)  
  1. In parenthesis: p-value after comparison with the Greek-Cypriot frequencies.