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Table 3 Allele frequencies of the four studied pharmacogenetic variants in Cyprus and comparison with other populations

From: Genetic polymorphisms in warfarin and tacrolimus-related genes VKORC1, CYP2C9 and CYP3A5 in the Greek-Cypriot population

Population group

No of tested chromosomes

VKORC1-1639A

CYP2C9*2

CYP2C9*3

CYP3A5*3

Reference

Greek-Cypriots

296

53.38%

16.20%

11.15%

94.26%

This study

Nicosia

106

62.26%

18.87%

9.43%

95.28%

Limassol

52

44.23%

19.23%

11.54%

96.15%

Ammochostos

60

51.67%

15.00%

15.00%

93.33%

Larnaka

28

50.00%

14.29%

7.14%

92.86%

Pafos

32

50.00%

9.38%

9.38%

90.63%

Kerynia

18

44.44%

11.11%

16.67%

94.44%

 

Caucasians

1362

37.81%

   

[21]

 

(P < 0.001)

    

3484

 

14.00%

6.40%

 

[12]

  

(P = 0.296)

(P = 0.002)

  

284

   

95.50%

[12]

     

(P = 0.526)

 

Africans

736

10.05%

   

[21]

 

(P < 0.001)

    

1376

 

2.20%

1.80%

 

[12]

  

(P < 0.0001)

(P < 0.001)

  

1330

   

31.80%

[12]

     

(P < 0.001)

 

Eastern Asians

1282

91.03%

   

[21]

 

(P < 0.001)

    

13284

 

<0.1%

3.30%

 

[12]

  

(P < 0.001)

(P < 0.001)

  

7658

   

76.10%

[12]

     

(P < 0.001)

 

Hellenes from Greece

656

44.40%

   

[22]

 

(P = 0.010)

    

566

 

12.90%

8.13%

94.35%

[17]

   

(P = 0.183)

(P = 0.144)

(P = 0.957)

 
  1. In parenthesis: p-value after comparison with the Greek-Cypriot frequencies.
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BMC Research Notes

ISSN: 1756-0500

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