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Table 2 List of the 20 genes most significantly up- and down-regulated in the Δcps mutant relative to wild-type levels

From: Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578

Locus

Gene product

Expression level (wild-type)

Expression level (Δcps)

p-value

Fold change

Up-regulated genes

KPN_00042

Hypothetical

9.00

13.38

0.0021

20.82

KPN_00321

Hypothetical

6.63

9.20

0.0007

5.92

KPN_01030

Hypothetical

8.15

10.65

0.0170

5.66

KPN_01107

Hypothetical

9.41

13.32

0.0021

15.03

KPN_01226

Periplasmic protein

10.59

13.27

0.0052

6.38

KPN_01279

Lipoprotein, osmotically inducible

11.03

13.96

0.0012

7.62

KPN_01568

Hypothetical

7.46

10.07

0.0085

6.10

KPN_01977

Lysozyme inhibitor

9.57

12.45

0.0007

7.34

KPN_02742

Hypothetical

8.95

11.38

0.0057

5.40

KPN_03160

Hypothetical

11.17

13.82

0.0028

6.30

KPN_04221

Periplasmic repressor CpxP

10.08

12.49

0.0044

5.32

KPN_04433

Putative stress-response protein

9.46

11.81

0.0083

5.09

KPN_04512a

N-glycosyl-transferase PgaC

6.40

9.74

0.0003

10.13

KPN_04513a

Putative polysaccharide deacetylase

6.38

9.79

0.0006

10.67

KPN_04514a

Outer membrane protein PgaA

6.43

10.95

0.0002

22.95

KPN_04515a

Hypothetical

6.56

12.30

0.0059

53.44

KPN_04516a

Hypothetical

7.64

11.25

0.0010

12.21

KPN_04684

Putative sulfate transporter

8.78

11.67

0.0013

7.41

KPN_04685

Putative carbonic anhydrase

10.50

13.32

0.0049

7.02

KPN_04773

Putative porin

9.17

12.04

0.0026

7.31

Down-regulated genes

KPN_00464

Copper exporting ATPase

10.44

8.48

0.0024

0.26

KPN_00626

methylthioribose kinase MtnK

11.02

9.38

0.0052

0.32

KPN_00688

tRNA-Gln-CTG

13.17

11.34

0.0213

0.28

KPN_00689

tRNA-Gln-CTG

13.01

11.26

0.0287

0.30

KPN_01055

tRNA-Ser-GGA

13.00

11.11

0.0341

0.27

KPN_01427

Hypothetical

9.12

7.35

0.0040

0.29

KPN_02433

tRNA-Asn-GTT

15.01

12.52

0.0365

0.18

KPN_02448

tRNA-Asn-GTT

14.91

12.54

0.0246

0.19

KPN_02488

dTDP-4-dehydrorhamnose 3,5-epimerase

12.69

11.02

0.0032

0.31

KPN_02489

dTDP-4-dehydrorhamnose reductase

13.06

11.18

0.0035

0.27

KPN_02593

Colicin I receptor

14.38

12.83

0.0034

0.34

KPN_02746

tRNA-Ala-GGC

10.11

8.52

0.0257

0.33

KPN_02747

tRNA-Ala-GGC

10.36

8.87

0.0377

0.36

KPN_02920

Bifunctional chorismate mutase/prephenate dehydratase

11.74

10.24

0.0092

0.35

KPN_03277b

Putative fimbrial usher protein

13.08

11.49

0.0024

0.33

KPN_03278b

Putative pili assembly chaperone

13.66

12.05

0.0024

0.33

KPN_04263

tRNA-Trp-CCA

10.89

8.38

0.0088

0.18

KPN_04300

tRNA-Pro-TGG

9.93

8.11

0.0193

0.28

KPN_04425

Maltoporin

11.34

9.61

0.0051

0.30

KPN_04776

Carbon starvation protein

9.26

7.63

0.0043

0.32

  1. aGenes associated with the pga operon.
  2. bGenes associated with the mrk type 3 fimbriae operon.
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BMC Research Notes

ISSN: 1756-0500

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