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Table 2 List of the 20 genes most significantly up- and down-regulated in the Δcps mutant relative to wild-type levels

From: Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578

Locus Gene product Expression level (wild-type) Expression level (Δcps) p-value Fold change
Up-regulated genes
KPN_00042 Hypothetical 9.00 13.38 0.0021 20.82
KPN_00321 Hypothetical 6.63 9.20 0.0007 5.92
KPN_01030 Hypothetical 8.15 10.65 0.0170 5.66
KPN_01107 Hypothetical 9.41 13.32 0.0021 15.03
KPN_01226 Periplasmic protein 10.59 13.27 0.0052 6.38
KPN_01279 Lipoprotein, osmotically inducible 11.03 13.96 0.0012 7.62
KPN_01568 Hypothetical 7.46 10.07 0.0085 6.10
KPN_01977 Lysozyme inhibitor 9.57 12.45 0.0007 7.34
KPN_02742 Hypothetical 8.95 11.38 0.0057 5.40
KPN_03160 Hypothetical 11.17 13.82 0.0028 6.30
KPN_04221 Periplasmic repressor CpxP 10.08 12.49 0.0044 5.32
KPN_04433 Putative stress-response protein 9.46 11.81 0.0083 5.09
KPN_04512a N-glycosyl-transferase PgaC 6.40 9.74 0.0003 10.13
KPN_04513a Putative polysaccharide deacetylase 6.38 9.79 0.0006 10.67
KPN_04514a Outer membrane protein PgaA 6.43 10.95 0.0002 22.95
KPN_04515a Hypothetical 6.56 12.30 0.0059 53.44
KPN_04516a Hypothetical 7.64 11.25 0.0010 12.21
KPN_04684 Putative sulfate transporter 8.78 11.67 0.0013 7.41
KPN_04685 Putative carbonic anhydrase 10.50 13.32 0.0049 7.02
KPN_04773 Putative porin 9.17 12.04 0.0026 7.31
Down-regulated genes
KPN_00464 Copper exporting ATPase 10.44 8.48 0.0024 0.26
KPN_00626 methylthioribose kinase MtnK 11.02 9.38 0.0052 0.32
KPN_00688 tRNA-Gln-CTG 13.17 11.34 0.0213 0.28
KPN_00689 tRNA-Gln-CTG 13.01 11.26 0.0287 0.30
KPN_01055 tRNA-Ser-GGA 13.00 11.11 0.0341 0.27
KPN_01427 Hypothetical 9.12 7.35 0.0040 0.29
KPN_02433 tRNA-Asn-GTT 15.01 12.52 0.0365 0.18
KPN_02448 tRNA-Asn-GTT 14.91 12.54 0.0246 0.19
KPN_02488 dTDP-4-dehydrorhamnose 3,5-epimerase 12.69 11.02 0.0032 0.31
KPN_02489 dTDP-4-dehydrorhamnose reductase 13.06 11.18 0.0035 0.27
KPN_02593 Colicin I receptor 14.38 12.83 0.0034 0.34
KPN_02746 tRNA-Ala-GGC 10.11 8.52 0.0257 0.33
KPN_02747 tRNA-Ala-GGC 10.36 8.87 0.0377 0.36
KPN_02920 Bifunctional chorismate mutase/prephenate dehydratase 11.74 10.24 0.0092 0.35
KPN_03277b Putative fimbrial usher protein 13.08 11.49 0.0024 0.33
KPN_03278b Putative pili assembly chaperone 13.66 12.05 0.0024 0.33
KPN_04263 tRNA-Trp-CCA 10.89 8.38 0.0088 0.18
KPN_04300 tRNA-Pro-TGG 9.93 8.11 0.0193 0.28
KPN_04425 Maltoporin 11.34 9.61 0.0051 0.30
KPN_04776 Carbon starvation protein 9.26 7.63 0.0043 0.32
  1. aGenes associated with the pga operon.
  2. bGenes associated with the mrk type 3 fimbriae operon.