The filtering process leading to the constitution of the confidence subset (CS) composed of 530 interactions through 4 cumulative filters. The 1st filter box excludes interaction in which protein partners are not co-detected in untreated macrophage. The 2nd filter holds only interactions which partners are known to share interactiong domain according to iPFAM. The 3rd filter maintains interactions with satisfying annotation parameters (GO Biological process, GO cellular component). The 4th parameter checks the reproducibility of the interaction with different experimental evidences or in different Pubmed publications.