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Table 2 Significant Odds Ratio (OR, 95% CI) between Control and Disease groups using genders, age and mtDNA polymorphism

From: Mitochondrial DNA association study of type 2 diabetes with or without ischemic stroke in Taiwan

Disease groups

Explanatory variables

Logistic regression

Fisher Exact test using SNPs between control and disease groups

  

Gender, age, population and haplogroups (Control = 327 Desease = 481)

SNP markers from complete sequencing (Control= 73, T2Dall=103, T2Donly=70, T2DIS=33, IS= 63)

SNP markers from partial sequencing (Control= 327, Disease= 481)

T2D With and without IS (T2Dall)

Gender

0.67, 0.51~0.89**

0.40, 0.21~0.74**

0.61, 0.48~0.78***

Population

1.7, 1.23~2.2***

-

1.7, 1.27~2.31***

B4a1a

-

3.93, 1.09~14.12*

-

B5a2b

-

-

2.13, 1.07~4.24*

D

0.53, 0.35~0.82**

-

0.42, 0.24~0.74**

D4

0.35, 0.18~0.66***

-

-

E1

-

-

1.95, 1.04~3.65*

F4b

-

-

2.56, 1.23~5.34*

T2Donly

Population

1.5, 1.1~2.0**

2.71, 1.37~5.49**

1.86, 1.36~2.55***

B4a1a

-

3.83, 1.01~14.54*

-

B5a2b

2.95, 1.23~7.05*

-

2.38, 1.18~4.79*

D

0.57, 0.37~0.90*

-

-

D4*

0.36, 0.18~0.72*

0.25, 0.07~0.93*

0.32, 0.17~0.61***

D5/M7

-

-

0.57, 0.33~0.98*

E

1.89, 1.15~3.10*

3.64, 1.25~10.64*

1.86, 1.16~2.97**

E1a1

-

2.99, 1.09~8.22*

1.86, 1.16~2.97**

E2b1

4.32, 1.36~13.72*

-

1.86, 1.16~2.97**

F4b

-

-

1.82, 1.03~3.22*

T2D with IS (T2DIS)

Gender

0.52, 0.29~0.91*

0.38, 0.16~0.89*

0.44, 0.28~0.69***

Age

1.06, 1.03~1.08***

nt

nt

B4a1a

3.90, 1.70~8.06***

5.19, 1.21~22.22*

2.34, 1.04~5.30*,

B4c1b2

4.39, 1.50~12.80**

-

-

Ischemic Stroke (ISonly)

Gender

0.51, 0.32~0.81**

0.29, 0.14~0.58***

0.48, 0.32~0.71***

age

1.10, 1.08~1.13***

nt

nt

F4b

-

-

3.09, 1.11~8.59*

  1. T2Dall _Type 2 Diabetes (T2D) with or without ischemic stroke (IS); T2Donly _T2D patient without IS; and T2DIS _T2D patient with IS; ISonly _IS patient with no T2D.
  2. SNPs obtained from partial sequencing include HVS1, np 8000 to np 9000 and np 9800 to np 10900 regions.
  3. P value * <0.05, ** < 0.01, *** < 0.001, nt: not tested.