Table 2 Patient characteristics, as categorized by treatment duration and discontinuation, all genotypes
From: High rates of early treatment discontinuation in hepatitis C-infected US veterans
Total (N = 20,499) | Discontinued for non-LOE reasons (N = 4637) | Discontinued due to LOE (N = 1408) | Unknown (N = 5202) | Completed ≥20/44 wks of therapy (N = 9252) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | % | CI-LL | CI-UL | N | % | CI-LL | CI-UL | N | % | CI-LL | CI-UL | N | % | CI-LL | CI-UL | N | % | CI-LL | CI-UL | |
DEMOGRAPHIC VARIABLES | ||||||||||||||||||||
Age | ||||||||||||||||||||
< 50 | 4636 | 22.6% | 22.1% | 23.1% | 964 | 20.8% | 19.8% | 21.8% | 288 | 20.5% | 18.7% | 22.2% | 1074 | 20.6% | 19.7% | 21.6% | 2310 | 25.0% | 24.2% | 25.7% |
50-64 | 15388 | 75.1% | 74.6% | 75.6% | 3557 | 76.7% | 75.7% | 77.7% | 1085 | 77.1% | 75.2% | 78.9% | 3983 | 76.6% | 75.6% | 77.5% | 6763 | 73.1% | 72.3% | 73.9% |
65+ | 475 | 2.3% | 2.1% | 2.5% | 116 | 2.5% | 2.1% | 2.9% | 35 | 2.5% | 1.8% | 3.2% | 145 | 2.8% | 2.4% | 3.2% | 179 | 1.9% | 1.7% | 2.2% |
BMI | ||||||||||||||||||||
< 18.5 | 88 | 0.4% | 0.4% | 0.5% | 34 | 0.7% | 0.5% | 0.9% | 6 | 0.4% | 0.1% | 0.7% | 16 | 0.3% | 0.2% | 0.4% | 32 | 0.3% | 0.2% | 0.4% |
18.5 – 24.9 | 4910 | 24.0% | 23.5% | 24.4% | 1179 | 25.4% | 24.4% | 26.5% | 316 | 22.4% | 20.6% | 24.3% | 1234 | 23.7% | 22.8% | 24.7% | 2181 | 23.6% | 22.8% | 24.3% |
25 – 29.9 | 8583 | 41.9% | 41.3% | 42.4% | 1941 | 41.9% | 40.7% | 43.1% | 620 | 44.0% | 41.9% | 46.2% | 2162 | 41.6% | 40.4% | 42.7% | 3860 | 41.7% | 40.9% | 42.6% |
30+ | 6708 | 32.7% | 32.2% | 33.3% | 1423 | 30.7% | 29.6% | 31.8% | 456 | 32.4% | 30.3% | 34.4% | 1736 | 33.4% | 32.3% | 34.4% | 3093 | 33.4% | 32.6% | 34.2% |
Unknown | 210 | 1.0% | 0.9% | 1.1% | 60 | 1.3% | 1.0% | 1.6% | 10 | 0.7% | 0.3% | 1.1% | 54 | 1.0% | 0.8% | 1.3% | 86 | 0.9% | 0.8% | 1.1% |
Marital status | ||||||||||||||||||||
Married | 6985 | 34.1% | 33.5% | 34.6% | 1459 | 31.5% | 30.3% | 32.6% | 501 | 35.6% | 33.5% | 37.7% | 1784 | 34.3% | 33.2% | 35.4% | 3241 | 35.0% | 34.2% | 35.8% |
Not married | 3480 | 17.0% | 16.5% | 17.4% | 798 | 17.2% | 16.3% | 18.1% | 259 | 18.4% | 16.7% | 20.1% | 821 | 15.8% | 15.0% | 16.6% | 1602 | 17.3% | 16.7% | 18.0% |
Other/unknown | 10034 | 48.9% | 48.4% | 49.5% | 2380 | 51.3% | 50.1% | 52.5% | 648 | 46.0% | 43.8% | 48.2% | 2597 | 49.9% | 48.8% | 51.1% | 4409 | 47.7% | 46.8% | 48.5% |
Race | ||||||||||||||||||||
White | 5375 | 26.2% | 25.7% | 26.7% | 1184 | 25.5% | 24.5% | 26.6% | 313 | 22.2% | 20.4% | 24.1% | 1243 | 23.9% | 22.9% | 24.9% | 2635 | 28.5% | 27.7% | 29.3% |
Black | 2738 | 13.4% | 13.0% | 13.7% | 741 | 16.0% | 15.1% | 16.9% | 274 | 19.5% | 17.7% | 21.2% | 873 | 16.8% | 15.9% | 17.6% | 850 | 9.2% | 8.7% | 9.7% |
Hispanic | 679 | 3.3% | 3.1% | 3.5% | 149 | 3.2% | 2.8% | 3.6% | 48 | 3.4% | 2.6% | 4.2% | 162 | 3.1% | 2.7% | 3.5% | 320 | 3.5% | 3.1% | 3.8% |
Other/unknown | 11706 | 57.1% | 56.5% | 57.7% | 2563 | 55.3% | 54.1% | 56.5% | 773 | 54.9% | 52.7% | 57.1% | 2923 | 56.2% | 55.1% | 57.3% | 5447 | 58.9% | 58.0% | 59.7% |
Sex (male) | 19708 | 96.1% | 95.9% | 96.4% | 4484 | 96.7% | 96.3% | 97.1% | 1359 | 96.5% | 95.7% | 97.3% | 5011 | 96.3% | 95.9% | 96.8% | 8854 | 95.7% | 95.4% | 96.0% |
LABORATORY VARIABLES | ||||||||||||||||||||
Genotype | ||||||||||||||||||||
G1/4 | 14,893 | 100% | NA | NA | 3562 | 23.9% | NA | NA | 1405 | 9.4% | NA | NA | 4560 | 30.6% | NA | NA | 5366 | 36.0% | NA | NA |
G2/3 | 5606 | 100% | NA | NA | 1075 | 19.2% | NA | NA | 3 | 0.1% | NA | NA | 642 | 11.5% | NA | NA | 3886 | 69.3% | NA | NA |
Albumin | ||||||||||||||||||||
< 3.5 mg/dL | 1139 | 5.6% | 5.3% | 5.8% | 312 | 6.7% | 6.1% | 7.3% | 90 | 6.4% | 5.3% | 7.5% | 354 | 6.8% | 6.2% | 7.4% | 383 | 4.1% | 3.8% | 4.5% |
3.5+ mg/dL (normal) | 17966 | 87.6% | 87.3% | 88.0% | 3973 | 85.7% | 84.8% | 86.5% | 1249 | 88.7% | 87.3% | 90.1% | 4486 | 86.2% | 85.5% | 87.0% | 8258 | 89.3% | 88.7% | 89.8% |
Missing | 1394 | 6.8% | 6.5% | 7.1% | 352 | 7.6% | 7.0% | 8.2% | 69 | 4.9% | 4.0% | 5.8% | 362 | 7.0% | 6.4% | 7.5% | 611 | 6.6% | 6.2% | 7.0% |
ALT | ||||||||||||||||||||
< 30 IU/mL (normal) | 1264 | 6.2% | 5.9% | 6.4% | 292 | 6.3% | 5.7% | 6.9% | 65 | 4.6% | 3.7% | 5.5% | 306 | 5.9% | 5.3% | 6.4% | 601 | 6.5% | 6.1% | 6.9% |
30-90 IU/mL (elevated 1x-3x ULN) | 10115 | 49.3% | 48.8% | 49.9% | 2306 | 49.7% | 48.5% | 50.9% | 750 | 53.3% | 51.1% | 55.5% | 2670 | 51.3% | 50.2% | 52.5% | 4389 | 47.4% | 46.6% | 48.3% |
90+ IU/mL (3+ x ULN) | 7788 | 38.0% | 37.4% | 38.5% | 1726 | 37.2% | 36.1% | 38.4% | 530 | 37.6% | 35.5% | 39.8% | 1857 | 35.7% | 34.6% | 36.8% | 3675 | 39.7% | 38.9% | 40.6% |
Missing | 1332 | 6.5% | 6.2% | 6.8% | 313 | 6.8% | 6.1% | 7.4% | 63 | 4.5% | 3.6% | 5.4% | 369 | 7.1% | 6.5% | 7.7% | 587 | 6.3% | 5.9% | 6.8% |
Bilirubin | ||||||||||||||||||||
< 1.5 mg/dL (normal) | 17327 | 84.5% | 84.1% | 84.9% | 3846 | 82.9% | 82.0% | 83.9% | 1220 | 86.6% | 85.2% | 88.1% | 4332 | 83.3% | 82.4% | 84.1% | 7929 | 85.7% | 85.1% | 86.3% |
1.5 + mg/dL | 1472 | 7.2% | 6.9% | 7.5% | 387 | 8.3% | 7.7% | 9.0% | 106 | 7.5% | 6.4% | 8.7% | 402 | 7.7% | 7.1% | 8.3% | 577 | 6.2% | 5.8% | 6.7% |
Missing | 1700 | 8.3% | 8.0% | 8.6% | 404 | 8.7% | 8.0% | 9.4% | 82 | 5.8% | 4.8% | 6.9% | 468 | 9.0% | 8.3% | 9.6% | 746 | 8.1% | 7.6% | 8.5% |
Creatinine | ||||||||||||||||||||
< 1.1 mg/dL (normal) | 2474 | 12.1% | 11.7% | 12.4% | 537 | 11.6% | 10.8% | 12.4% | 219 | 15.6% | 14.0% | 17.1% | 611 | 11.7% | 11.0% | 12.5% | 1107 | 12.0% | 11.4% | 12.5% |
1.1 + mg/dL | 2062 | 10.1% | 9.7% | 10.4% | 505 | 10.9% | 10.1% | 11.6% | 147 | 10.4% | 9.1% | 11.8% | 529 | 10.2% | 9.5% | 10.9% | 881 | 9.5% | 9.0% | 10.0% |
Missing | 15963 | 77.9% | 77.4% | 78.3% | 3595 | 77.5% | 76.5% | 78.5% | 1042 | 74.0% | 72.1% | 75.9% | 4062 | 78.1% | 77.1% | 79.0% | 7264 | 78.5% | 77.8% | 79.2% |
Hemoglobin | ||||||||||||||||||||
Anemiac | 754 | 3.7% | 3.5% | 3.9% | 196 | 4.2% | 3.7% | 4.7% | 46 | 3.3% | 2.5% | 4.0% | 242 | 4.7% | 4.2% | 5.1% | 270 | 2.9% | 2.6% | 3.2% |
13+ g/dL m.; 12+ g/dL f. (normal) | 18425 | 89.9% | 89.5% | 90.2% | 4090 | 88.2% | 87.4% | 89.0% | 1288 | 91.5% | 90.3% | 92.7% | 4617 | 88.8% | 88.0% | 89.5% | 8430 | 91.1% | 90.6% | 91.6% |
Missing | 1320 | 6.4% | 6.2% | 6.7% | 351 | 7.6% | 6.9% | 8.2% | 74 | 5.3% | 4.3% | 6.2% | 343 | 6.6% | 6.0% | 7.2% | 552 | 6.0% | 5.6% | 6.4% |
LDL | ||||||||||||||||||||
< 100 mg/dL (normal) | 6745 | 32.9% | 32.4% | 33.4% | 1574 | 33.9% | 32.8% | 35.1% | 537 | 38.1% | 36.0% | 40.3% | 1847 | 35.5% | 34.4% | 36.6% | 2787 | 30.1% | 29.3% | 30.9% |
100 + mg/dL | 9811 | 47.9% | 47.3% | 48.4% | 2195 | 47.3% | 46.1% | 48.5% | 636 | 45.2% | 43.0% | 47.4% | 2332 | 44.8% | 43.7% | 46.0% | 4648 | 50.2% | 49.4% | 51.1% |
Missing | 3943 | 19.2% | 18.8% | 19.7% | 868 | 18.7% | 17.8% | 19.7% | 235 | 16.7% | 15.1% | 18.3% | 1023 | 19.7% | 18.8% | 20.6% | 1817 | 19.6% | 19.0% | 20.3% |
Platelet | ||||||||||||||||||||
< 100/mm3 | 865 | 4.2% | 4.0% | 4.5% | 255 | 5.5% | 4.9% | 6.1% | 69 | 4.9% | 4.0% | 5.8% | 236 | 4.5% | 4.1% | 5.0% | 305 | 3.3% | 3.0% | 3.6% |
100 +/mm3 (normal) | 18202 | 88.8% | 88.4% | 89.2% | 4023 | 86.8% | 85.9% | 87.6% | 1259 | 89.4% | 88.1% | 90.8% | 4583 | 88.1% | 87.4% | 88.8% | 8337 | 90.1% | 89.6% | 90.6% |
Missing | 1432 | 7.0% | 6.7% | 7.3% | 359 | 7.7% | 7.1% | 8.4% | 80 | 5.7% | 4.7% | 6.7% | 383 | 7.4% | 6.8% | 8.0% | 610 | 6.6% | 6.2% | 7.0% |