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Table 2 Patient characteristics, as categorized by treatment duration and discontinuation, all genotypes

From: High rates of early treatment discontinuation in hepatitis C-infected US veterans

  Total (N = 20,499) Discontinued for non-LOE reasons (N = 4637) Discontinued due to LOE (N = 1408) Unknown (N = 5202) Completed ≥20/44 wks of therapy (N = 9252)
N % CI-LL CI-UL N % CI-LL CI-UL N % CI-LL CI-UL N % CI-LL CI-UL N % CI-LL CI-UL
DEMOGRAPHIC VARIABLES                    
Age                     
< 50 4636 22.6% 22.1% 23.1% 964 20.8% 19.8% 21.8% 288 20.5% 18.7% 22.2% 1074 20.6% 19.7% 21.6% 2310 25.0% 24.2% 25.7%
50-64 15388 75.1% 74.6% 75.6% 3557 76.7% 75.7% 77.7% 1085 77.1% 75.2% 78.9% 3983 76.6% 75.6% 77.5% 6763 73.1% 72.3% 73.9%
65+ 475 2.3% 2.1% 2.5% 116 2.5% 2.1% 2.9% 35 2.5% 1.8% 3.2% 145 2.8% 2.4% 3.2% 179 1.9% 1.7% 2.2%
BMI                     
< 18.5 88 0.4% 0.4% 0.5% 34 0.7% 0.5% 0.9% 6 0.4% 0.1% 0.7% 16 0.3% 0.2% 0.4% 32 0.3% 0.2% 0.4%
18.5 – 24.9 4910 24.0% 23.5% 24.4% 1179 25.4% 24.4% 26.5% 316 22.4% 20.6% 24.3% 1234 23.7% 22.8% 24.7% 2181 23.6% 22.8% 24.3%
25 – 29.9 8583 41.9% 41.3% 42.4% 1941 41.9% 40.7% 43.1% 620 44.0% 41.9% 46.2% 2162 41.6% 40.4% 42.7% 3860 41.7% 40.9% 42.6%
30+ 6708 32.7% 32.2% 33.3% 1423 30.7% 29.6% 31.8% 456 32.4% 30.3% 34.4% 1736 33.4% 32.3% 34.4% 3093 33.4% 32.6% 34.2%
Unknown 210 1.0% 0.9% 1.1% 60 1.3% 1.0% 1.6% 10 0.7% 0.3% 1.1% 54 1.0% 0.8% 1.3% 86 0.9% 0.8% 1.1%
Marital status                     
Married 6985 34.1% 33.5% 34.6% 1459 31.5% 30.3% 32.6% 501 35.6% 33.5% 37.7% 1784 34.3% 33.2% 35.4% 3241 35.0% 34.2% 35.8%
Not married 3480 17.0% 16.5% 17.4% 798 17.2% 16.3% 18.1% 259 18.4% 16.7% 20.1% 821 15.8% 15.0% 16.6% 1602 17.3% 16.7% 18.0%
Other/unknown 10034 48.9% 48.4% 49.5% 2380 51.3% 50.1% 52.5% 648 46.0% 43.8% 48.2% 2597 49.9% 48.8% 51.1% 4409 47.7% 46.8% 48.5%
Race                     
White 5375 26.2% 25.7% 26.7% 1184 25.5% 24.5% 26.6% 313 22.2% 20.4% 24.1% 1243 23.9% 22.9% 24.9% 2635 28.5% 27.7% 29.3%
Black 2738 13.4% 13.0% 13.7% 741 16.0% 15.1% 16.9% 274 19.5% 17.7% 21.2% 873 16.8% 15.9% 17.6% 850 9.2% 8.7% 9.7%
Hispanic 679 3.3% 3.1% 3.5% 149 3.2% 2.8% 3.6% 48 3.4% 2.6% 4.2% 162 3.1% 2.7% 3.5% 320 3.5% 3.1% 3.8%
Other/unknown 11706 57.1% 56.5% 57.7% 2563 55.3% 54.1% 56.5% 773 54.9% 52.7% 57.1% 2923 56.2% 55.1% 57.3% 5447 58.9% 58.0% 59.7%
Sex (male) 19708 96.1% 95.9% 96.4% 4484 96.7% 96.3% 97.1% 1359 96.5% 95.7% 97.3% 5011 96.3% 95.9% 96.8% 8854 95.7% 95.4% 96.0%
LABORATORY VARIABLES                    
Genotype                     
G1/4 14,893 100% NA NA 3562 23.9% NA NA 1405 9.4% NA NA 4560 30.6% NA NA 5366 36.0% NA NA
G2/3 5606 100% NA NA 1075 19.2% NA NA 3 0.1% NA NA 642 11.5% NA NA 3886 69.3% NA NA
Albumin                     
< 3.5 mg/dL 1139 5.6% 5.3% 5.8% 312 6.7% 6.1% 7.3% 90 6.4% 5.3% 7.5% 354 6.8% 6.2% 7.4% 383 4.1% 3.8% 4.5%
3.5+ mg/dL (normal) 17966 87.6% 87.3% 88.0% 3973 85.7% 84.8% 86.5% 1249 88.7% 87.3% 90.1% 4486 86.2% 85.5% 87.0% 8258 89.3% 88.7% 89.8%
Missing 1394 6.8% 6.5% 7.1% 352 7.6% 7.0% 8.2% 69 4.9% 4.0% 5.8% 362 7.0% 6.4% 7.5% 611 6.6% 6.2% 7.0%
ALT                     
< 30 IU/mL (normal) 1264 6.2% 5.9% 6.4% 292 6.3% 5.7% 6.9% 65 4.6% 3.7% 5.5% 306 5.9% 5.3% 6.4% 601 6.5% 6.1% 6.9%
30-90 IU/mL (elevated 1x-3x ULN) 10115 49.3% 48.8% 49.9% 2306 49.7% 48.5% 50.9% 750 53.3% 51.1% 55.5% 2670 51.3% 50.2% 52.5% 4389 47.4% 46.6% 48.3%
90+ IU/mL (3+ x ULN) 7788 38.0% 37.4% 38.5% 1726 37.2% 36.1% 38.4% 530 37.6% 35.5% 39.8% 1857 35.7% 34.6% 36.8% 3675 39.7% 38.9% 40.6%
Missing 1332 6.5% 6.2% 6.8% 313 6.8% 6.1% 7.4% 63 4.5% 3.6% 5.4% 369 7.1% 6.5% 7.7% 587 6.3% 5.9% 6.8%
Bilirubin                     
< 1.5 mg/dL (normal) 17327 84.5% 84.1% 84.9% 3846 82.9% 82.0% 83.9% 1220 86.6% 85.2% 88.1% 4332 83.3% 82.4% 84.1% 7929 85.7% 85.1% 86.3%
1.5 + mg/dL 1472 7.2% 6.9% 7.5% 387 8.3% 7.7% 9.0% 106 7.5% 6.4% 8.7% 402 7.7% 7.1% 8.3% 577 6.2% 5.8% 6.7%
Missing 1700 8.3% 8.0% 8.6% 404 8.7% 8.0% 9.4% 82 5.8% 4.8% 6.9% 468 9.0% 8.3% 9.6% 746 8.1% 7.6% 8.5%
Creatinine                     
< 1.1 mg/dL (normal) 2474 12.1% 11.7% 12.4% 537 11.6% 10.8% 12.4% 219 15.6% 14.0% 17.1% 611 11.7% 11.0% 12.5% 1107 12.0% 11.4% 12.5%
1.1 + mg/dL 2062 10.1% 9.7% 10.4% 505 10.9% 10.1% 11.6% 147 10.4% 9.1% 11.8% 529 10.2% 9.5% 10.9% 881 9.5% 9.0% 10.0%
Missing 15963 77.9% 77.4% 78.3% 3595 77.5% 76.5% 78.5% 1042 74.0% 72.1% 75.9% 4062 78.1% 77.1% 79.0% 7264 78.5% 77.8% 79.2%
Hemoglobin                     
Anemiac 754 3.7% 3.5% 3.9% 196 4.2% 3.7% 4.7% 46 3.3% 2.5% 4.0% 242 4.7% 4.2% 5.1% 270 2.9% 2.6% 3.2%
13+ g/dL m.; 12+ g/dL f. (normal) 18425 89.9% 89.5% 90.2% 4090 88.2% 87.4% 89.0% 1288 91.5% 90.3% 92.7% 4617 88.8% 88.0% 89.5% 8430 91.1% 90.6% 91.6%
Missing 1320 6.4% 6.2% 6.7% 351 7.6% 6.9% 8.2% 74 5.3% 4.3% 6.2% 343 6.6% 6.0% 7.2% 552 6.0% 5.6% 6.4%
LDL                     
< 100 mg/dL (normal) 6745 32.9% 32.4% 33.4% 1574 33.9% 32.8% 35.1% 537 38.1% 36.0% 40.3% 1847 35.5% 34.4% 36.6% 2787 30.1% 29.3% 30.9%
100 + mg/dL 9811 47.9% 47.3% 48.4% 2195 47.3% 46.1% 48.5% 636 45.2% 43.0% 47.4% 2332 44.8% 43.7% 46.0% 4648 50.2% 49.4% 51.1%
Missing 3943 19.2% 18.8% 19.7% 868 18.7% 17.8% 19.7% 235 16.7% 15.1% 18.3% 1023 19.7% 18.8% 20.6% 1817 19.6% 19.0% 20.3%
Platelet                     
< 100/mm3 865 4.2% 4.0% 4.5% 255 5.5% 4.9% 6.1% 69 4.9% 4.0% 5.8% 236 4.5% 4.1% 5.0% 305 3.3% 3.0% 3.6%
100 +/mm3 (normal) 18202 88.8% 88.4% 89.2% 4023 86.8% 85.9% 87.6% 1259 89.4% 88.1% 90.8% 4583 88.1% 87.4% 88.8% 8337 90.1% 89.6% 90.6%
Missing 1432 7.0% 6.7% 7.3% 359 7.7% 7.1% 8.4% 80 5.7% 4.7% 6.7% 383 7.4% 6.8% 8.0% 610 6.6% 6.2% 7.0%
  1. cAnemia defined as hemoglobin <12 g/dL if female or <13 g/dL if male.
  2. Key: CI – 95% confidence interval; LL – lower limit; UL – upper limit; NA – Not applicable; D/C – discontinuation; LOE – lack of efficacy; (ref) – reference value; BMI - body mass index; VISN – Veterans Integrated Service Network; COPD - chronic obstructive pulmonary disease; HIV - human immunodeficiency virus; ALT - alanine aminotransferase; ULN – upper limit of normal; LDL - low density lipoprotein.