Experimental group
|
Number of pigsa
|
Pig age at inoculation
|
Inoculation strain
|
Treatment
|
---|
Probiotic
|
30
|
24-26 days
|
S1191c
|
CWF308 (pJCPGb4)
|
Sham
|
30
|
24-26 days
|
S1191c
|
CWF308
|
Negative control
|
10
|
24-26 days
|
123b
|
None
|
- aEach group represents the cumulative number of pigs from three separate experimental replications. bNon-pathogenic E. coli strain. cSTEC strain.
- Three week old piglets were orally inoculated with either pathogenic STEC strain 1191 (probiotic and sham groups) or non-pathogenic E. coli strain 123 (negative control group). STEC inoculated pigs were treated with either a Shiga toxin 2e receptor mimic probiotic (probiotic group) or a sham probiotic strain which lacked the receptor mimic (sham group). Treatment was administered twice daily, and was initiated 24 hours post-inoculation with the STEC strain.