Incidences of clinical disease and vascular lesions in pigs inoculated with Shiga toxin-producingEscherichia coliand treated with a probiotic strain expressing a Shiga toxin receptor mimic vs. a sham strain lacking the receptor mimic
aInoculated with STEC strain, treated with probiotic. bInoculated with STEC strain, treated with sham. cInoculated with non-pathogenic E. coli strain, no treatment. dSum of three experimental replicates.
Negative control pigs were inoculated with a non-pathogenic, commensal E.coli strain. Probiotic treatment had a tendency to reduce the incidence of vascular lesions in brainstem (p = 0.098); however, treatment with the receptor mimic probiotic did not significantly reduce the incidences of clinical disease or vascular lesions (Fisher’s exact test).