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Table 1 Patient characteristics at the time of initial visit to a medical facility

From: Long-term survival of patients with pulmonary arterial hypertension recovering to World Health Organization functional class I or II: a historical comparison between intravenous epoprostenol and oral agents

Variables

All

Group 1

Group 2

Group 3

Group 4

Age (years) *

43 ± 22

38 ± 18

48 ± 22

52 ± 21

66 ± 9

Women/Men

34 (83) / 7 (17)

10 (24) / 0 (0)

6 (15) / 3 (7)

9 (22) / 0 (0)

9 (22) / 1 (2)

WHO-FC†§

II/III/IV

2(5) / 29(71) / 10(24)

0 (0) / 12 (29) / 1 (2)

0 (0) / 5 (12) / 4 (10)

2 (5) / 7 (17) / 0 (0)

0 (0) / 5 (12) / 5 (12)

Etiology

Idiopathic

22(54)

9 (22)

6 (15)

2 (5)

5 (12)

Heritable

1(2)

0 (0)

0 (0)

1 (2)

0 (0)

CTD

SSc

12(29)

1 (2)

3 (7)

4 (10)

4 (10)

MCTD

3(7)

2 (5)

0 (0)

1 (2)

0 (0)

SLE

2(5)

1 (2)

0 (0)

1 (2)

0 (0)

PM

1(2)

0 (0)

0 (0)

0 (0)

1 (2)

Hemodynamics*

mPAP (mmHg)

51 ± 16

57 ± 21

53 ± 5

43 ± 13

45 ± 11

RAP (mmHg)

8 ± 6

6 ± 4||

8 ± 4

6 ± 4#

14 ± 8||,#

CI (L/min/m2)

2.1 ± 0.6

2.1 ± 0.6

2.3 ± 0.5

1.9 ± 0.5

2.1 ± 0.6

PVR (dyne/sec/cm−5)

1058 ± 492

1368 ± 439

981 ± 314

884 ± 526

1039 ± 605

SvO2 (%)

60 ± 10

61 ± 9

50 ± 17

63 ± 9

60 ± 10

6MWD (m)*

 

196 ± 188

267 ± 164

150 ± 230

401 ± 39**

56 ± 106**

  1. *Average ± standard deviation, Number (%) of patients, p = 0.004 between Group 1 and 4, §p = 0.010, **p = 0.03 between Group 3 and 4, ||p = 0.02 between Group 1 and 4, #p = 0.02 between Group 3 and 4 in RAP. CI: cardiac index, CTD: connective tissue disease, MCTD: mixed connective tissue disease, mPAP: mean pulmonary arterial pressure, PM: polymyositis, PVR: pulmonary vascular resistance, RAP: right atrial pressure, SLE: systemic lupus erythematosus, SSc: scleroderma, SvO2: oxygen saturation of mixed venous blood, WHO-FC: World Health Organization functional class, 6MWD: 6-minute-walk distance.