Table 1 Patient characteristics in relation to without and with recurrence CCRCC
Characteristic | Total | Without recurrence group | With recurrence group | P-value |
|---|---|---|---|---|
(n = 83) | (n = 71) | (n = 12) | ||
Age (years) | ||||
Median [range] | 67 [23-83] | 67 [23-83] | 65 [44-82] | 0.820 |
Gender (%) | ||||
Male | 52 (63) | 48 (68) | 4 (33) | |
Female | 31 (37) | 23 (32) | 8 (67) | 0.049 |
ECOG PS (%) | ||||
0 | 81 (98) | 70 (99) | 11 (92) | |
1 | 1 (1) | 1 (1) | 0 (0) | |
2 | 1 (1) | 0 (0) | 1 (8) | 0.046 |
T stage (%) | ||||
T1 | 64 (77) | 60 (85) | 4 (33) | |
T2 | 5 (6) | 4 (5) | 1 (9) | |
T3 | 14 (17) | 7 (10) | 7 (58) | |
T4 | 0 (0) | 0 (0) | 0 (0) | <0.001 |
Grade (%) | ||||
1 | 7 (8) | 5 (7) | 2 (17) | |
2 | 70 (84) | 64 (90) | 6 (50) | |
3 | 6 (8) | 2 (3) | 4 (33) | <0.001 |
UISS risk classification (%) | ||||
Low risk | 61 (73) | 58 (82) | 3 (25) | |
Intermediate risk | 21 (25) | 13 (18) | 8 (67) | |
High risk | 1 (2) | 0 (0) | 1 (8) | <0.001 |
Histological vein invasion (%) | ||||
No | 53 (64) | 48 (68) | 5 (42) | |
Yes | 30 (36) | 23 (32) | 7 (58) | 0.083 |
Tumor necrosis (%) | ||||
No | 70 (84) | 64 (90) | 6 (50) | |
Yes | 13 (16) | 7 (10) | 6 (50) | <0.001 |
Symptoms (%) | ||||
No | 59 (71) | 52 (73) | 7 (58) | |
Yes | 24 (29) | 19 (27) | 5 (42) | 0.292 |
IHC staining (%) | ||||
Grade 0 | 39 (47) | 37 (52) | 2 (17) | |
Grade 1+ | 18 (22) | 15 (21) | 3 (25) | |
Grade 2+ | 19 (23) | 15 (21) | 4 (33) | |
Grade 3+ | 7 (8) | 4 (6) | 3 (25) | 0.045 |
Tumor size (mm) | ||||
Median [range] | 40.0 [12-120] | 40.0 [12-90] | 43.5 [30-120] | 0.118 |
Hemoglobin (g/dL ) | ||||
Median [range] | 13.4 [8.1-17.0] | 13.55 [9.6-17.0] | 12.2 [8.1-14.7] | 0.014 |
Corrected Ca (mg/dL) | ||||
Median [range] | 9.30 [8.5-11.2] | 9.25 [8.5-10.8] | 9.35 [8.6-11.2] | 0.606 |
CRP (mg/dL) | ||||
Median [range] | 0.20 [0.0-12.4] | 0.20 [0.0-12.4] | 0.35 [0.0-6.2] | 0.335 |
Serum VEGF (pg/mL) | ||||
Median [range] | 299 [42-1460] | 290 [42-1460] | 478 [140-982] | 0.038 |