| |
Not ventilated infants
|
Intubated and ventilated < 7days
|
Intubated and ventilated ≥ 7days
|
p-value
|
|---|
|
N = 84
|
N = 47
|
N = 45
|
|---|
|
Tidal breathing
| | | | |
|
VT (mL/kg)
|
8.61
|
8.01
|
7.68**
|
0.034
|
|
(7.37 - 9.80)
|
(6.70 - 9.67)
|
(6.96 - 8.64)
|
|
RR (1/min)
|
40.9
|
44.8
|
44.4*
|
0.045
|
|
(36.0 - 47.1)
|
(35.5 - 56.1)
|
(38.0 - 55.7)
|
|
V’E (mL/min/kg)
|
346.2
|
373.0
|
353.0
|
0.452
|
|
(297.8 - 398.4)
|
(311.2 - 407.3)
|
(299.0 - 402.7)
|
|
tptef/te (%)
|
20.7%
|
22.1%
|
21.1%
|
0.898
|
| |
(17.4% - 26.2%)
|
(16.3% - 27.0%)
|
(17.1% - 27.2%)
| |
|
te (s)
|
0.857
|
0.770
|
0.753*
|
0.025
|
| |
(0.720 - 0.962)
|
(0.593 - 0.990)
|
(0.577 - 0.861)
| |
|
PTIF (mL/s/kg)
|
18.9
|
19.6
|
18.0
|
0.351
|
| |
(15.4 - 21.3)
|
(16.6 - 22.6)
|
(16.4 - 20.7)
| |
|
PTEF (mL/s/kg)
|
17.1
|
18.0
|
17.9
|
0.150
|
| |
(14.6 - 19.4)
|
(15.2 - 22.0)
|
(14.5 - 20.9)
| |
|
MTIF (mL/s/kg)
|
13.4
|
14.0
|
13.1
|
0.642
|
| |
(11.5 - 15.4)
|
(12.0 - 16.3)
|
(11.8 - 15.7)
| |
|
MTEF (mL/s/kg)
|
10.0
|
11.1
|
10.4
|
0.375
|
| |
(8.6 - 12.0)
|
(9.3 - 12.5)
|
(8.9 - 13.0)
| |
|
Respiratory mechanics
| | | | |
|
Crs (mL/kPa/kg)
|
10.6
|
9.2
|
8.9***
|
0.002
|
| |
(9.0 - 11.0)
|
(7.6 - 11.6)
|
(6.7 - 10.5)
| |
|
Rrs (kPa/L/s)
|
5.96
|
6.55
|
6.15
|
0.094
|
| |
(4.61 - 7.30)
|
(5.07 - 8.62)
|
(5.17 - 7.86)
| |
|
Exhalation gas analysis
| | | | |
|
eNO (ppb)
|
10.0
|
6.6**
|
10.4
|
0.005
|
| |
(6.3 - 13.6)
|
(4.2 - 10.7)
|
(7.2 - 13.8)
| |
|
V’NO (nL/s)
|
0.50
|
0.39**
|
0.54
|
0.005
|
| |
(0.34 - 0.72)
|
(0.24 - 0.54)
|
(0.37 - 0.66)
| |
|
Blood gas analysis
| | | | |
|
paO2 (mmHg)
|
73.3
|
66.6*
|
65.6***
|
< 0.001
|
| |
(65.5 - 83.0)
|
(58.6 - 78.0)
|
(58.5 - 70.9)
| |
|
paCO2 (mmHg)
|
39.9
|
42.2*
|
44.6***
|
< 0.001
|
| |
(37.7 - 43.7)
|
(39.1 - 45.8)
|
(41.1 - 47.3)
| |
- *p < 0.05, ** p < 0.01, *** p < 0.001 when compared to not ventilated infants. Data represent median (interquartile range). Statistically significant values are printed in bold.
