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Table 2 Comparative functional analysis of confirmed target of human hsa-mir-143-3p and predicted target of animal orthologs

From: Computational prediction of disease microRNAs in domestic animals

Species

Functional mature miRNA

Target gene symbol

Target gene length

% identity human-animal AKT1 (full-length alignment)

AKT1 predicted biological processes (UniProtKB GO)*

mir-143 target inhibition

Human

hsa-miR-143-3p

AKT1 (Confirmed)

480 aa

100

Glucose homeostasis, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, response to food, glucose transport.

Cleavage

Pig

ssc-miR-143-3p

AKT1 (Predicted)

480 aa

100

Glucose homeostasis, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, response to food, glucose transport.

Cleavage

Horse

eca-miR-143

AKT1 (Predicted)

479 aa

98

Glucose homeostasis, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, response to food, glucose transport

Cleavage

Dog

cfa-miR-143

AKT1 (Predicted)

479 aa

97

Glucose homeostasis, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, response to food, glucose transport

Cleavage

  1. Over-expression of hsa-miR-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism [83].
  2. *Showing only the biological process GO terms with direct relevance to type 2 diabetes.